Mutant hypoxia inducible factor-1 HIF-1

Details Mutant hypoxia inducible factor-1 HIF-1 Mutant hypoxia inducible factor-1 HIF-1

1998-08-25

2000-09-26

LeGuyader, John L.

Chemistry: molecular biology and microbiology

Animal cell, per se ; composition thereof; process of...

435 691, 4352523, 4353201, 536 231, 536 235, C07K 1600, C12N 1512, C12N 1574, C12N 1585

Patent

active

061241318

ABSTRACT:
Substantially purified stable human hypoxia-inducible factor-1.alpha. (sHIF-1.alpha.) mutein is provided. Polynucleotides encoding stable human hypoxia-inducible factor-1.alpha. mutein are also provided. A method is provided for treating a hypoxia-related tissue damage in a subject by administering to the subject a therapeutically effective amount of a sHIF-1.alpha. mutein or a nucleotide sequence including an expression control sequence operatively linked to a polynucleotide encoding a stable hypoxia-inducible factor-1.alpha. mutein. Formulations are provided for the administration of stable human hypoxia inducible factor-1.alpha. (HIF-1.alpha.) polypeptide or a polynucleotide encoding stable human hypoxia inducible factor-1.alpha. (HIF-1.alpha.) to a patient having hypoxia-related tissue damage.

REFERENCES:
Verma et al. Nature. 389: 239-241, Sep. 18, 1997.
Miller et al. FASEB. 9: 190-199, 1995.
Eck et al. Goodman and Gilman's The Pharmacological Basis of Therapeutics. NY: McGraw-Hill. Chap. 5, p. 81-82, 1995.
Fujiwara et al., Expressed Sequence Tag (EST), GenBank Accession Numbers D56430, D53682, R71408, T32121, HS14513, T32145, T35966, M85743, R71117, T32012, and Q60265. GenBank. May 30, 1995, see sequence alignments.
Benjamin et al., Activation of the Heat Shock Transcription Factor by Hypoxia in Mammalian Cells, Aug. 1990, Proceedings of the National Academy of Science USA, vol. 87, pp. 6263-6267.
Wang et al., Hypoxia-Inducible Factor 1 is a Basic-Helix-Loop-Helix-PAS Heterodimer Regulated by Cllular 02 Tension, Jun. 1995, Proceedings of the National Academy of Science USA, vol. 92, pp. 5510-5514.
Norris et al., Hypoxia-Induced Protein Binding to 02-Responsive Sequences on the Tyrosine Hydroxylase Gene, Oct. 6, 1995, Journal of Biological Chemistry, vol. 270, pp. 23774-23779.
Dejgaard et al., Identification, Molecular Cloning, Expression and Chromosome Mapping of a Family of Transformation Upregulated hnRNP-K Proteins Dervied by Alternative Splicing, 1994, J. Mol. Biol., vol. 236, pp. 33-48.

Affiliated with

Also associated with

Rating

Mutant hypoxia inducible factor-1 HIF-1 does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Mutant hypoxia inducible factor-1 HIF-1, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Mutant hypoxia inducible factor-1 HIF-1 will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-2099061