Mutant human T cell line producing immunosuppressive factor and

Chemistry: molecular biology and microbiology – Spore forming or isolating process

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530351, 435 68, 4351721, 435948, C12N 500, C12N 1500, A61K 3702, C12R 191

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active

047286148

ABSTRACT:
A stable mutant human T cell line is disclosed which secretes a high titer suppressor inducer factor. This suppressor inducer factor in turn induces production of a T cell suppressor factor which suppressed mitogen-induced T cell proliferation at high dilution. Also disclosed is a general method for mutating lymphoblastoid cell lines to yield mutants secreting enhanced levels of lymphokines.

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