Mutant human hepatitis B viral strain and uses thereof

Details Mutant human hepatitis B viral strain and uses thereof Mutant human hepatitis B viral strain and uses thereof

2006-09-12

2006-09-12

Li, Bao Qun (Department: 1648)

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Amino acid sequence disclosed in whole or in part; or...

C424S227100, C435S069100

Reexamination Certificate

active

07105165

ABSTRACT:
This invention provides an isolated strain of Hepatitis B virus designated Human Hepatitis B Virus Surface Antigen-‘S’-133 Oon Strain (Methionine to Threonine) which constituent viral genome is deposited under Accession Nos. P97121501, P97121502 and P97121503 with the European Collection of Cell Culture on 15thDec. 1997. This invention also provides an isolated nucleic acid encoding a polypeptide which is a mutant major surface antigen of a strain of hepatitis B virus, such polypeptide having an amino acid sequence which differs from the amino acid sequence of a major surface antigen of a wild type hepatitis B virus in that the amino acid at position number 133 of such polypeptide is a threonine rather than a methionine. This invention also provides an isolated nucleic acid which encodes a peptide, wherein the peptide is encoded by a nucleic acid molecule comprising nucleotides 527 through 595 of SEQ. I.D. No. 1 and the purified peptide. This invention also provides various methods of using the disclosed isolated nucleic acid and peptides.

REFERENCES:
patent: 9521189 (1995-08-01), None
patent: 9811916 (1998-03-01), None
Galibert, F., et al. “Nucleotide Sequence of a Cloned Woodchuck Hepatitis . . . ” Journal of Virology (1982) vol. 41 pp. 51-65.
Takeshima, H., et al. “Structural Analysis of the Gene Coding for Hepatitis B Virus Surface Antigen and its Product” Journal of General Virology (1985) vol. 66 pp. 195-200.
Fujiyama, A., et al. “Cloning and Structural Analyses of Hepatitis B Virus DNAs, Subtype adr” Nucleic Acids Research (1983) vol. 11, No. 13 pp. 4601-4610.
Norder, H., et al. “Genetic Relatedness of Hepatitis B Viral Strains of Diverse Geographical Origin . . . ” Journal of General Virology (1993) vol. 74 pp. 1341-1348.
Don Ganem, Fields, Virology Third Edition, (1996) vol. 2 pp. 2741-2447.

Affiliated with

Also associated with

Rating

Mutant human hepatitis B viral strain and uses thereof does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Mutant human hepatitis B viral strain and uses thereof, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Mutant human hepatitis B viral strain and uses thereof will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-3592837