Mutant having uracil phosphoribosyl transferase activity

Details Mutant having uracil phosphoribosyl transferase activity Mutant having uracil phosphoribosyl transferase activity

2005-10-31

2009-08-11

Kaushal, Sumesh (Department: 1633)

Drug, bio-affecting and body treating compositions

Whole live micro-organism, cell, or virus containing

Genetically modified micro-organism, cell, or virus

C424S093100, C514S04400A, C435S320100, C435S325000, C435S455000

Reexamination Certificate

active

07572438

ABSTRACT:
The invention concerns a polypeptide having a uracil phosphoribosyl transferase (UPRTase) by mutation of one or several residues of the UPRTase. The invention also concerns a nucleotide sequence coding for the UPRTase mutant, a vector for expressing the latter, a viral particle, a host cell, and a composition containing them. The invention further concerns their therapeutic use and a treatment method using them. The invention is particularly useful in the context of therapy by suicide genes, in particular, for treating proliferative and infectious diseases.

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patent: 96/16183 (1996-05-01), None
Oonuma, et al. Gene therapy for intraperitoneally disseminated pancreatic cancers byEscherichia coliuracil phophoribosiltransferase (UPRT) gene mediated by restricted replication-competent adenoviral vectors. International Journal of Cancer, 2002. 102:51-59.
Bourbeau, et al. Suicide gene therapy with an adenovirus expressing the fusion gene CD:UPRT in human glioblastomas: different sensitivities correlate with p53 status. The Journal of Gene Medicine, 2004. 6:1320-1332.
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Kem, L. et al., “The FUR1 Gene ofSaccharomyces cerevisiae: Cloning, Structure and Expression of Wild-Type and Mutant Alleles”, Gene Apr. 16, 1990, 88(2), 149-57, Elsevier Science Publishers B.V. (Biomedical Division).
Martinussen et al., “Two Genes Encoding Uracil-Phosphoribosyltransferase are present inBacillus subtilis,” J. Bacteriol. 177 (1):271-274, Jan. 1995, Am. Soc. Of Microbiology, Wash., D.C.
GenBank Acc. No. CAB11230, “Uracil Phosphoribosyltransferase (Schizosaccharomyces Pombe),” US Natl. Library of Medicine, Bethesda, MD, Apr. 4, 2000, accessed by PTO on 04 No. 2002.
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