Mutant glucose dehydrogenase

Details Mutant glucose dehydrogenase Mutant glucose dehydrogenase

2006-06-12

2009-10-20

Pak, Yong D (Department: 1652)

Chemistry: molecular biology and microbiology

Enzyme , proenzyme; compositions thereof; process for...

Oxidoreductase

C435S004000, C435S006120, C435S026000, C435S069100, C435S071100, C435S252300, C435S320100, C435S440000, C536S023200

Reexamination Certificate

active

07604969

ABSTRACT:
A mutant glucose dehydrogenase having an improved substrate specificity to glucose, which is a protein comprising the amino acid sequence depicted in SEQ ID NO:3 or an amino acid sequence having the substitution, deletion, insertion or addition of one or more amino acid residues excluding amino acid 365 in the amino acid sequence depicted in SEQ ID NO:3 and having a glucose dehydrogenase activity, the amino acid residue corresponding to amino acid 365 being substituted by other amino acid residue.

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Inose, et al., “Cloning and Expression of the Gene Encoding Catalytic Subunit of Thermostable Glucose Dehydrogenase fromBurkholderia cepaciainEscherichia coli,” Biochimica et Biophysica Acta, vol. 1645, pp. 133-138, 2003.
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Yoshida, et al. “Engineering a Chimeric Pyrroloquinoline Quinone Glucose Dehydrogenase: Improvement of EDTA Tolerance, Thermal Stability and Substrate Specificity,”Protein Engineering, vol. 12, No. 1, p. 63-70, 1999.
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