Mutant forms of EtxB and CtxB and their use as carriers

Details Mutant forms of EtxB and CtxB and their use as carriers Mutant forms of EtxB and CtxB and their use as carriers

2003-12-22

2008-09-09

Paras, Peter (Department: 1632)

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

C424S257100, C424S261100, C514S002600

Reexamination Certificate

active

07422752

ABSTRACT:
The present invention describes the use of a mutant form of EtxB or CtxB to deliver an agent to a target cell wherein the mutant has GM-1 binding activity; but wherein the mutant has a reduced immunogenic and immunomodulatory activity relative to the wild type form of EtxB or CtxB.

REFERENCES:
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patent: WO 00/14114 (2000-03-01), None
patent: WO 01/27144 (2001-04-01), None
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Marcello, Proceedings of the National Academy of Science, USA, 91:8994-8998.
Nashar et al (Nashar ref. “b”), International Immunology, 13:541-551, 2001.

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