Mutant forms of cholera holotoxin as an adjuvant

Details Mutant forms of cholera holotoxin as an adjuvant Mutant forms of cholera holotoxin as an adjuvant

2008-04-22

2008-04-22

Navarro, Mark (Department: 1645)

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Combination of viral and bacterial antigens

C424S261100, C424S161100, C530S350000

Reexamination Certificate

active

07361355

ABSTRACT:
Mutant cholera holotoxins comprising a cholera toxin subunit A having single amino acid substitutions in the amino acid positions 16 or 72 or a double amino acid substitution in the amino acid positions 16 and 68 or 68 and 72 have reduced toxicity compared to the wild-type cholera holotoxin. The mutant cholera holotoxins are useful as adjuvants in immunogenic compositions to enhance the immune response in a vertebrate host to a selected antigen from a pathogenic bacterium, virus, fungus, or parasite, a cancer cell, a tumor cell, an allergen, or a self-molecule.

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