Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Preparing alpha or beta amino acid or substituted amino acid...
Patent
1992-08-07
1995-01-03
Naff, David M.
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Preparing alpha or beta amino acid or substituted amino acid...
4352528, 435848, 435849, C12P 1314, C12N 100, C12N 120
Patent
active
053786165
ABSTRACT:
The present invention provides a mutant and a process for producing L-glutamic acid by fermentation using a microorganism belonging to the genus Escherichia. In the present process, L-glutamic acid is produced and accumulated in a culture medium by (A) culturing an Escherichia mutant which is deficient or low in .alpha.-ketoglutaric acid dehydrogenase activity, has low L-glutamic acid decomposing ability, and is capable of producing L-glutamic acid.
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The Journal of Biochemistry, vol. 50, No. 2, 1961, Tokyo JP pp. 164-165 Isamu Shiio et al `Significance of alpha-ketoglutaric dehydrogenase on the glutamic acid formation in Brevibacterium flavum`.
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Kawahara Yoshiko
Kikuchi Yoshimi
Kurahashi Osamu
Tujimoto Nobuharu
Ajinomoto Co. Inc.
Naff David M.
Ware Deborah K.
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