Mutant EPO receptor and uses therefor

Details Mutant EPO receptor and uses therefor Mutant EPO receptor and uses therefor

1990-12-13

1994-03-08

Nucker, Christine M.

Chemistry: molecular biology and microbiology

Spore forming or isolating process

435 6, 435 694, 435 695, 435 696, 536 235, 530350, 530351, 935 10, 935 11, 935 66, 935 70, 935 72, C12Q 168, C12P 2106, C12N 500, C07H 1512, C07H 1700, C07K 300, C07K 1300, C07K 1500, C07K 1700

Patent

active

052926540

ABSTRACT:
A mutant erythropoietin receptor of mammalian origin which is hypersensitive to erythropoietin, DNA encoding the mutant erythropoietin receptor and uses therefor. An assay method for identifying compounds which mimic erythropoietin is also disclosed.

REFERENCES:
D'Andrea et al (Dec. 1990) The Cytoplasmic Region of the Erythropoietin Receptor . . . Blood 76:89(A) Abstract 348.
Jones et al. (1990 Jul.) Human Erythropoietin Receptor . . . Blood 76:31-35.
D'Andrea, A. D., et al., Mol. Cell. Biol. 11(4):1980-7. (Apr. 1991).
Yoshimura, A. et al., Nature 348 647-649 (Dec. 13, 1990).
Quelle, D. E. and Wojchowski, D. M., Proc. Natl. Acad. Sci. USA 88: (11):4801-5 (Jun. 1, 1991).
D. Andrea, A D., et al Cell 57:277-285 (Apr. 21, 1989).

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