Mutant E. coli strain with increased succinic acid production

Details Mutant E. coli strain with increased succinic acid production Mutant E. coli strain with increased succinic acid production

1995-11-02

1998-06-23

Lilling, Herbert J.

Chemistry: molecular biology and microbiology

Micro-organism, per se ; compositions thereof; proces of...

Bacteria or actinomycetales; media therefor

435140, 435145, 4352528, 435849, C12N 120, C12P 754, C12P 746

Patent

active

057704350

ABSTRACT:
A method for isolating succinic acid producing bacteria is provided comprising increasing the biomass of an organism which lacks the ability to catabolize pyruvate, and then subjecting the biomass to glucose-rich medium in an anaerobic environment to enable pyruvate-catabolizing mutants to grow.
The invention also provides for a mutant that produces high amounts of succinic acid, which as been derived from a parent which lacked the genes for pyruvate formate lyase and lactate dehydrogenase, and which belongs to the E.coli Group of Bacteria.

REFERENCES:
patent: 5143834 (1992-09-01), Glassner et al.
patent: 5521075 (1996-05-01), Guettler et al.
patent: 5573931 (1996-11-01), Guettler et al.

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