Drug – bio-affecting and body treating compositions – Conjugate or complex of monoclonal or polyclonal antibody,... – Conjugated to proteinaceous toxin or fragment thereof
Patent
1994-10-17
1998-08-11
Scheiner, Toni R.
Drug, bio-affecting and body treating compositions
Conjugate or complex of monoclonal or polyclonal antibody,...
Conjugated to proteinaceous toxin or fragment thereof
4241551, 4241741, 424 941, 424832, 514 12, 530350, 5303877, 5303917, C12N 900, A61K 3944, A61K 3816, A61K 39395
Patent
active
057924589
ABSTRACT:
A potent and specific immunotoxin is prepared by coupling an inactivated diphtheria toxin to a binding moiety such as a monoclonal antibody or transferrin. The immunotoxins are specific for human tumors and leukemias and are indistinguishable in cell toxicity from that of the native toxin linked to the binding domain without the toxicity to other cells. The immunotoxin is useful in treating graft versus host disease as well as selectively killing tumor cells, such as medulloblastoma and glioblastoma cells.
REFERENCES:
patent: 4520226 (1985-05-01), Neville et al.
patent: 4545985 (1985-10-01), Pastan et al.
patent: 4675382 (1987-06-01), Murphy
patent: 4830962 (1989-05-01), Gelford et al.
patent: 4894443 (1990-01-01), Greenfield et al.
patent: 4956453 (1990-09-01), Bjorn et al.
patent: 4981979 (1991-01-01), Sivam
patent: 5045451 (1991-09-01), Uhr
patent: 5066490 (1991-11-01), Neville et al.
patent: 5154924 (1992-10-01), Friden
patent: 5169956 (1992-12-01), Neville et al.
patent: 5182107 (1993-01-01), Fridan
patent: 5208021 (1993-05-01), Johnson et al.
patent: 5352447 (1994-10-01), Johnson et al.
Trowbridge et al (1981) Nature 294: 171-173.
Youle et al (1980) Proc. Natl. Acad. Sci. USA 77: 5483-5486.
Domingo et al (1985) Methods Enzymol. 112: 238-247.
Youle et al (1986 Jan.) J. Immunol. 136(1): 93-98.
Laird et al, Journal of Virology, vol. 19, No. 1, pp. 220-227 (1976).
Annual Progress Report, U.S. Army Medical Research Institute of Infectious Diseases, pp. 95-96 (1981).
Zovickian et al, J. Neurosurg., vol. 68, pp. 767-774 (1988).
Neville, Jr. et al, The Journal of Biological Chemistry, vol. 264, No. 25, pp. 14653-14661 (1989).
Greenfield et al, Science, vol. 238, pp. 536-539 (1987).
Richard Youle et al., Proc. Natl. Acad. Sci. USA, vol. 76, No. 11, pp. 5559-5562 (1979).
Richard Youle et al., Cell, vol. 23, pp. 551-559 (1981).
Colombatti, M. et al. Journal of Biological Chemistry 261(7):3030-3035, Mar. 1986.
O'Keefe et al (1985) J. Biol. Chem. 260(2):932-937.
Zovickian et al (1987) J. Neurosurg. 66:850-861.
Goldstein et al (1986) Scientific America 255:74-83.
Bach et al (1993) Immunology Today 14:421-425.
Waldmann (1991) Science 252:1657-1662.
Jach (1994) Scientific American (Jul. issue):58-65.
Gregonadis et al (1993) Trends in Biotech 11:440-442.
Rott (1991) "Essential Immunology", Blackwell Scientific Publications Oxford, pp. 65-68 & 74.
Piedel et al (1990) Proc. Nat'l Acad. Sci. 87:5051-5055.
Sovza et al (1995) Proc. Natl. Acad. Sci. 92:959-963.
Largo et al (1988) Molec. Cell. Biol. 8(3):1247-1252.
Esworthy et al (1984) J. Biol. Chem. 259(18):11496-11504.
Morrison et al (1972) "Organic Chemistry," Allyer and Bacon, Inc., Boston, p. 6.
Johnson et al (1989) J. Neurosurg: 70:240-248.
Youle (1991) Semin. Cell Biol. 2: 39-45.
Youle et al (1988) In "Immunotoxins" (A.E. Frankel, ed.), Kluiver Academic Publications, pp. 113-119.
Youle et al, The Journal of Immunology, vol. 136, No. 1, pp. 93-98, Jan. 1986.
Akiyamas et al, Cancer Research, vol. 45, pp. 1005-1007, 1985.
Jeffries et al (1984) Nature 312: 162-163.
Akiyama et al, Cancer Research, vol. 45, pp. 1005-1007, 1985.
Seto et al, Cancer Research, vol. 42, pp. 5209-5215, Dec. 1982.
Greenfield Larry
Johnson Virginia G.
Laird Walter
Youle Richard J.
Cetus Corporation
Lucas John
Scheiner Toni R.
The United States of America as represented by the Department of
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