Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Preparing alpha or beta amino acid or substituted amino acid...
Reexamination Certificate
2006-01-31
2006-01-31
Slobodyansky, Elizabeth (Department: 1652)
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Preparing alpha or beta amino acid or substituted amino acid...
C435S087000, C435S089000, C435S183000, C435S252300, C435S252330, C536S023200
Reexamination Certificate
active
06991924
ABSTRACT:
L-arginine, citrulline and pyrimidine derivatives including orotic acid, uridine, uridine 5′-monophosphate (UMP), cytidine and cytidine 5′-monophosphate (CMP) are produced using a bacterium belonging to the genusEscherichiaharboring a mutant carbamoylphosphate synthetase in which the amino acid sequence corresponding to positions from 947 to 951 in a wild type carbamoylphosphate synthetase is replaced with any one of amino acid sequences of SEQ ID NOS: 1 to 9, and feedback inhibition by uridine 5′-monophosphate in the bacterium is desensitized.
REFERENCES:
Nyunoya et al. (1983) PNAS, vol. 80, pp. 4629-4633.
J. B. Thoden, et al.,Biochemistry, vol. 36, No. 21, pp. 6305-6316, “Structure of Carbamoyl Phosphate Synthetase: a Journey of 96 a from Substrate to Product”, 1997.
J. B. Thoden, et al., Acta Crystallographica, Section D, vol. 55, pp. 8-24, “The Structure of Carbamoyl Phospahate Synthetase Determined to 2.1 Åresolution”, 1999.
S. Delannay, et al., J. Mol. Biol., vol. 286, pp. 1217-1228, “Serine 948 and Threonine 1042 are Crucial Residues for Allosteric Regulation ofEscherichia coliCarbamoylphosphate Systhetase and Illustrate Coupling Effects of Activation and Inhibition Pathways”, 1999.
F. R. Blattner, et al., Science, Accession No. AE000113 U00096, pp. 1-8, “the Complete Genome Sequence ofEscherichia coliK-12”, 1997 (Abstract only of vol. 277, No. 5331, pp. 1453-1474).
Altman Irina Borisovna
Gusyatiner Mikhail Markovich
Kotliarova Veronika Aleksandrovna
Novikova Anna Eugenievna
Ptitsyn Leonid Romanovich
Ajinomoto Co. Inc.
Oblon & Spivak, McClelland, Maier & Neustadt P.C.
Slobodyansky Elizabeth
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