Mutant bacterium belonging to the genus Bacillus

Details Mutant bacterium belonging to the genus Bacillus Mutant bacterium belonging to the genus Bacillus

2005-03-04

2010-12-21

Noakes, Suzanne M (Department: 1656)

Chemistry: molecular biology and microbiology

Micro-organism, per se ; compositions thereof; proces of...

Bacteria or actinomycetales; media therefor

C435S071100, C435S471000, C435S485000

Reexamination Certificate

active

07855065

ABSTRACT:
The present invention provides a mutantBacillusbacterium capable of enhancing productivity of proteins or polypeptides, a recombinant microorganism produced by introducing genes encoding heterologous proteins or polypeptides into the mutantBacillusbacterium, and a method for producing proteins or polypeptides by use of the recombinant microorganism. A mutantBacillusbacterium which has, on the genome or plasmid thereof, DNA having a promoter sequence which is recognized and transcribed specifically during the sporulation stage and which is ligated to an upstream end of a sigA gene or a gene equivalent thereto, a recombinant microorganism produced by introducing genes encoding heterologous proteins or polypeptides into the mutantBacillusbacterium, and a method for producing proteins or polypeptides by use of the recombinant microorganism.

REFERENCES:
patent: 1 065 277 (2001-01-01), None
patent: 1 350 843 (2003-10-01), None
patent: 6 327472 (1994-11-01), None
patent: 2000 184882 (2000-07-01), None
patent: 2000 210081 (2000-08-01), None
patent: 2003 054179 (2003-07-01), None
Hengge-Aronis, Current Opinion in Microbiology, 2002, 5: pp. 591-595.
Schnider, U. et al.,“Amplification of the housekeeping sigma factor in Pseudomonas flourescens CHAO enhances antibiotic production and improves biocontrol abilities”, J. Bacteriol., vol. 177, No. 18. pp. 5387-5392, 1995.
Heldenwang, W. G. et al.,“ The sigma factors ofBacillus subtilis”, Microbiol. Rev., vol. 59, No. 1, pp. 1-30, 1995.
Bird, T. et al.,“The effect of supercoiling on the in vitro transcription of the spollA operon fromBacillus subtilis”, Biochimie, vol. 74, pp. 627-634, 1992.
Park, S.G. et al.,“Sequencing and phylogenetic analysis of the spollA operon from diverseBacillus and Paenibacillusspecies”, Gene, vol. 194, pp. 25-33, 1997.
Karen A. Hicks, et al., “Altering the level and regulation of the major sigma subunit of RNA polymerase affects gene expression and development inBacilus subtilis”, Molecular Microbiology, vol. 20, No. 1, XP002940914, 1996, pp. 201-212.
T. Kobayashi, et al. “Purification and Properties of an Alkaline Protease FromAlkalophilic Bacillussp. KSM-K16”, Applied Microbiology and Biotechnology, XP-002434999, vol. 43, No. 3, Jul. 1995, 3 pages.
Office Action issued Sep. 14, 2010, in Japanese Application No. 2005-060483, filed Sep. 8, 2010 (with English-language Translation).
Qi, et al., “Localization of a Second SigH Promoter in theBacillus subtilissigA Operon and Regulation of dnaE Expresison by the Promoter”, Journal of Bacteriology, vol. 172, No. 10, Oct. 1990, pp. 5631-5636.

Affiliated with

Also associated with

Rating

Mutant bacterium belonging to the genus Bacillus does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Mutant bacterium belonging to the genus Bacillus, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Mutant bacterium belonging to the genus Bacillus will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-4162747