Mutant aspartase and the preparation thereof

Details Mutant aspartase and the preparation thereof Mutant aspartase and the preparation thereof

1997-04-18

2000-01-18

Achutamurthy, Ponnathapura

Chemistry: molecular biology and microbiology

Enzyme , proenzyme; compositions thereof; process for...

Lyase

435106, 435109, 43525233, 536 232, C12N 988

Patent

active

060157046

ABSTRACT:
Disclosed is a mutant aspartase comprising the amino acid sequence of a wild-type E. coli aspartase wherein the amino acid residue at one of positions 25, 123, 421 and 463 is substituted. Also disclosed is a process for preparing the above mutant aspartase.

REFERENCES:
Zhang et al. "Enzymatic genration of mutant libraries in vivo for random mutagensis of aspartase gene" Chines Science Bulletin 37 (7), 598-601; Apr. 1992.
Yumoto, et al Physiol. Chem. Phys. 14 391-397 (1982) Studies on Aspartase VIII. Protease-Mediated Activation: Comparative Survey of Protease Specificity for Activation and Peptide Cleavage.
Murase, et al Biochem. Biophys. Res. Commun. 177 No. 1 414-419 (1991) Activation of Aspartase By Site-Directed Mutagenesis.
Zhang, et al Biochem. Biophys. Res. Commun. 192 No. 1 15-21 (1993) Z Enhancement of the Stability and Activity of Aspartase By Random and Site-Directed Mutagenesis.

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