Mutagenic nucleoside analogs for the treatment of viral disease

Details Mutagenic nucleoside analogs for the treatment of viral disease Mutagenic nucleoside analogs for the treatment of viral disease

2007-07-17

2007-07-17

Crane, L. E. (Department: 1623)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

C514S051000, C536S028540, C536S027400

Reexamination Certificate

active

10226799

ABSTRACT:
The present invention relates to methods of treating viral disease using mutagenic nucleoside analogs. In particular, the invention provides 5-aldehydo-uracil nucleosides and derivatives thereof, and methods of administration thereof to increase the virus mutation rate in a virally infected cell.

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Mertes et al., “Synthesis of 5-Formyl-2′-deoxyuridine and the α-Anomer,”Journal of Heterocyclic Chemistry, 7, 751 (Jun., 1970).

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