Mutagenesis testing using transgenic non-human animals carrying

Details Mutagenesis testing using transgenic non-human animals carrying Mutagenesis testing using transgenic non-human animals carrying

1993-09-23

1996-04-23

Chambers, Jasemine C.

Drug, bio-affecting and body treating compositions

In vivo diagnosis or in vivo testing

Testing efficacy or toxicity of a compound or composition

424 91, 800 2, 800DIG1, 4351723, 4353201, 4353171, 935 31, 935 72, 935 73, 935111, A61K 4900, C12N 1500

Patent

active

055100996

ABSTRACT:
An assay for monitoring and assessing the mutagenic potential of agents which involves creating transgenic non-human animals carrying a test DNA sequence or sequences that can be quickly recovered and examined for mutations following exposure to one or more suspected mutagenic agents.

REFERENCES:
patent: 5347075 (1994-09-01), Sorge
Ptashne, "A Genetic Switch: Gene Control and Phage Lambda", Blackwell Scientific Publ., Inc. Palo Alto, Calif. (1986).
Gossen et al., Nucleic Acids Res. 16(19):9343 (1988).
Raleigh et al., Nucleic Acids Res. 16(4):1563-1575 (1988).
Bickle, "Nucleases", pp. 85-108, Linn et al. eds., Cold Spring Harbor Laboratory, Cold Spring Harbor, N.Y. (1985).
Heitman et al., J. Bacteriol., 169:3243-3250 (1987).
Herrero et al., J. Bacteriol., 172:6557-6567 (1990).
Raleigh et al., Proc. Natl. Acad. Sci. USA, 83:9070-9074 (1986).
Ross et al., J. Bacteriol., 171:1974-1981 (1989).

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