Mutagenesis testing using transgenic non-human animals carrying

Details Mutagenesis testing using transgenic non-human animals carrying Mutagenesis testing using transgenic non-human animals carrying

1991-06-06

1994-09-13

Chambers, Jasemine C.

Multicellular living organisms and unmodified parts thereof and

Nonhuman animal

800DIG1, 4351723, 4353201, 4353171, 424 2, 424 9, 935 31, 935 72, 935 73, 935111, C12N 1500

Patent

active

053470753

ABSTRACT:
An assay for monitoring and assessing the mutagenic potential of agents which involves creating transgenic non-human animals carrying a test DNA sequence or sequences that can be quickly recovered and examined for mutations following exposure to one or more suspected mutagenic agents.

REFERENCES:
patent: 4736866 (1988-04-01), Leder et al.
Tice et al., "Modern Biological Theories of Aging" Warner et al., eds, p. 214, Raven Press (1987).
Palmiter et al., Cell 41: 343-345 (1985).
Glazer et al., Proc. Natl. Acad. Sci. 83: 1041-1044 (1986).
Singh et al., Canadian J. Genet. & Cytology 28: 286-293 (1986).
Lohman et al., Mutation Res. 181: 227-234 (1987).
Summers et al., Mutation Res. 220: 263-268 (1989).

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