Mutagenesis testing using transgenic non-human animals carrying

Details Mutagenesis testing using transgenic non-human animals carrying Mutagenesis testing using transgenic non-human animals carrying

1995-06-05

1998-10-20

Campbell, Bruce R.

Drug, bio-affecting and body treating compositions

In vivo diagnosis or in vivo testing

Testing efficacy or toxicity of a compound or composition

4351723, 800 2, 800DIG1, 935 59, A61K 4900, C12N 500, C12N 1500

Patent

active

058242872

ABSTRACT:
An assay for monitoring and assessing the mutagenic potential of agents which involves creating transgenic non-human animals carrying a test DNA sequence or sequences that can be quickly recovered and examined for mutations following exposure to one or more suspected mutagenic agents.

REFERENCES:
MJ Dycaico et al (1994) Mutation Research 307: 461-478.
JG de Boer et al (1996) Mutation Research 352: 73-78.
GS Provost et al (1993) Mutation Research 288: 133-149.

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