Mutagenesis testing using transgenic non-human animals carrying

Details Mutagenesis testing using transgenic non-human animals carrying Mutagenesis testing using transgenic non-human animals carrying

1995-05-31

1999-09-21

Low, Christopher S. F.

Drug, bio-affecting and body treating compositions

In vivo diagnosis or in vivo testing

Testing efficacy or toxicity of a compound or composition

424 91, 43525233, 4352523, 4351723, 4353201, 4352351, 800 2, 800DIG1, 536 231, 536 2372, 536 237, 536 241, A61K 4900

Patent

active

059550562

ABSTRACT:
An assay for monitoring and assessing the mutagenic potential of agents which involves creating transgenic non-human animals carrying a test DNA sequence or sequences that can be quickly recovered and examined for mutations following exposure to one or more suspected mutagenic agents.

REFERENCES:
patent: 5510099 (1996-04-01), Short et al.
Gossen et al. 1988 Nuc. Acids Res. 16(19): 9343.
Raleigh et al. 1988 Nuc. Acids Res. 16(4): 1563-1575.
Ptashne 1986 in: A Genetic Switch, Cell Press & Blackwell Scientific Publ., Palo Alto, CA, pp. 13-31, 49-67, 69-108.
Herrero et al. 1990 J. Bacteriol. 172(11): 6557-6567.

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