Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives
Reexamination Certificate
2007-07-03
2007-07-03
Weber, Jon (Department: 1656)
Organic compounds -- part of the class 532-570 series
Organic compounds
Carbohydrates or derivatives
C536S023100, C536S023500, C435S069100, C435S320100, C435S252300, C435S325000, C530S358000
Reexamination Certificate
active
10740052
ABSTRACT:
The present invention relates to a novel nucleotide sequence and the amino acid sequence encoded therein which comprise a novel gene and protein called Mustang. The present invention also relates to methods and compositions based on these sequences. These sequences are useful in the medical diagnosis, growth and regeneration of bone.
REFERENCES:
patent: 6475735 (2002-11-01), Sugiura
Malek et al. “cDNA clone RGIBG05 fromRattus norvegicus,” SEQ ID No. 1 alignment result 2, Database: EST, Accession No. BF281834, Nov. 28, 2000.
Malek et al. “cDNA clone RGIBG05 fromRattus norvegicus,” SEQ ID No. 2 alignment result 1, Database: EST, Accession No. BF281834, Nov. 28, 2000.
Jingushi et al., “Genetic expression of extracellular matrix proteins correlates with histologic changes during fracture repair,” J bone Miner Res. Sep. 1992;7(9):1045-55.
Hannouche et al., “Current trends in the enhancement of fracture healing.,” J Bone Joint Surg Br. Mar. 2001;83(2):157-64.
Sandberg et al., “Gene expression during bone repair,” Clin Orthop Relat Res. Apr. 1993;(289):292-312.
Hirakawa et al., “Localization of the mRNA for bone matrix proteins during fracture healing as determined by in situ hybridization,” J bone Miner Res. Oct. 1994;9(10):1551-7.
Hiltunen et al., “Expression of type VI, IX and XI collagen genes and alternative splicing of type II collagen transcripts in fracture callus tissue in mice,” FEBS Lett. May 8, 1995;364(2):171-4.
Yamazaki et al., “Spatial and temporal expression of fibril-forming minor collagen genes (types V and XI) during fracture healing,” J Orthop Res. Sep. 1997;15(5):757-64.
Linkhart et al., “Growth factors for bone growth and repair: IGF, TGF beta and BMP,” Bone. Jul. 1996;19(1 Suppl): 1S-12S.
Barnes et al., “Growth factor regulation of fracture repair,” J Bone Miner Res. Nov. 1999;14(11):1805-15.
Zhu et al., “Nitric oxide synthase isoforms during fracture healing,” Bone Miner Res. Mar. 2001;16(3):535-40.
Sakano et al., “Cartilage-derived retinoic acid-sensitive protein and type II collagen expression during fracture healing are potential targets for Sox9 regulation,” J Bone Miner Res. Nov. 1999; 14(11):1891-901.
Uusitalo et al., “Accelerated up-regulation of L-Sox5, Sox6, and Sox 9 by BMP-2 gene transfer during murine fracture healing,” J Bone Miner Res. Oct. 2001;16(10):1837-45.
Einhorn et al., “The expression of cytokine activity by fracture callus,” J Bone Miner Res. Aug. 1995;10(8):1272-81.
Ohta et al., “Midkine is expressed during repair of bone fracture and promotes chondrogenesis,” J Bone Miner Res. Jul. 1999;14(7):1132-44.
Einhorn et al., “The cell and molecular biology of fracture healing,” Clin Orthop Relat Res. Oct. 1998(355 Suppl):S7-21.
Matsui et al., “Identification of a dual leucine zipper kinase involved in rat fracture repair,” Biochem Biophys Res Commun. Dec. 13, 1996;229(2):571-6.
Diwan et al., “Nitric oxide modulates fracture healing,” J Bone Miner Res. Feb. 2000;15(2):342-51.
Hadjiargyrou Michael
Komatsu David
Lombardo Frank
Medlen & Carroll LLP
Mitra Rita
Research Foundation of State University of New York at Stony Bro
Weber Jon
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