Mussel bioadhesive

Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues

Reexamination Certificate

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C435S069100

Reexamination Certificate

active

07947806

ABSTRACT:
The present invention relates to a bioadhesive derived from mussel. In particular, it relates to a novel MGFP-3A MUTANT(Mytilus galloprovincialisfoot protein type-3A MUTANT) protein and a recombinant protein that is a hybrid of MGFP-3A MUTANT, FP(Foot Protein)-1 and MGFP-5(Mytilus galloprovincialisfoot protein type-5). According to the present invention, the adhesive protein can be economically produced in large scale and can be used instead of chemical adhesives.

REFERENCES:
patent: 5202236 (1993-04-01), Maugh et al.
patent: 6451579 (2002-09-01), Jessee et al.
patent: 08-266282 (1996-10-01), None
Inoue et al., Cloning, sequencing and sites of expression of genes for the hydroxyarginine-containing adhesive-plaque protein of the musselMytilus galloprovincialis, Eur. J. Biochem. 239:172-176, 1996.
English Machine translation from Japanese of JP08-266282-A, Nov. 18, 2009.
NCBI Accession No. BAB16314 (Oct. 4, 2000).
Hwang, D.S., et al. “Expression of Functional Recombinant Mussel Adhesive Protein Mgfp-5 inEscherichia coli” Applied and Environmental Microbiology, vol. 70 (6): pp. 3352-3359 (Jun. 2004).
NCBI Accession No. Q27409(Jan. 25, 2005).
Miki, D., et al. “Expression Sites of Two Byssal Protein Genes ofMytilus galloprovincialis” Biol. Bull., vol. 190: pp. 213-217 (Apr. 1996).

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