Muscle relaxant pharmaceutical compositions

Details Muscle relaxant pharmaceutical compositions Muscle relaxant pharmaceutical compositions

1996-01-16

1998-06-16

Henley, Raymond

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Cyclopentanohydrophenanthrene ring system doai

424450, A61K 3158, A61K 9127

Patent

active

057671125

ABSTRACT:
The invention relates to pharmaceutical compositions for parenteral administration. The compositions comprise an amount of neuromuscular blocking agent effective to produce muscular relaxation, and at least one zwitterionic substance having an isoionic point not greater than 7. The zwitterionic substance is present in an amount of between about 2 and about 30 percent by weight, based on the weight of the composition. The resulting composition has a pH of less than 7.

REFERENCES:
patent: 3553212 (1971-01-01), Hewett et al.
patent: 3872091 (1975-03-01), Hewett et al.
patent: 4110326 (1978-08-01), Tuba et al.
patent: 4237126 (1980-12-01), Carlyle et al.
patent: 4297351 (1981-10-01), Carlyle et al.
patent: 5418223 (1995-05-01), Palepu et al.
patent: 5469854 (1995-11-01), Unger et al.
patent: 5472706 (1995-12-01), Friedman et al.
Reminton's Pharmaceutical Sciences, 16th ed. pp. 1483-1484 1980.
W.R. Buckett et al; Pancuronium Bromide and Other Steroidal Neuromuscular Blocking Agents Containing Acetylcholine Fragments; Journal of Medicinal Chemistry 16 No. 10; pp. 1116-1124 (1973).

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