Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Patent
1994-12-19
1996-10-01
Datlow, Philip I.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
514220, 540551, 540557, A61K 3155, C07D40304, C07D41304, C07D41700
Patent
active
055611273
ABSTRACT:
Described herein are D4 receptor-selective compounds of the general formula I: ##STR1## wherein: A and B are independently selected, optionally substituted, saturated or unsaturated 5- or 6-membered, homo- or heterocyclic rings;
REFERENCES:
patent: 3539573 (1970-11-01), Schmutz
patent: 3546226 (1970-12-01), Schmutz
patent: 3751415 (1973-08-01), Schmutz
patent: 3758479 (1973-09-01), Schmutz
patent: 3908010 (1975-09-01), Schmutz
patent: 3983234 (1976-09-01), Sayers
patent: 4096261 (1978-06-01), Horrom
patent: 5006522 (1991-04-01), Engel
patent: 5354747 (1994-10-01), Hansen
Bloom et al J Pharmacology and Experimental Therapeutics, 1987, 240(1):51 "Characterization of high affinity [.sup.3 H]pirenzepine and (-)-[.sup.3 H]quinuclidinyl benzilate binding to muscarinic cholinergic receptors in rabbit peripheral lung".
Clark et al J Med Chem, 1993, 36:2645 "2-(quinuclidin-3-yl)pyridol[4,3-]b indol-1-ones and isoquinolin-1 ones. Potent conformationally restricted 5-H%3 receptor antagonists".
Gianai et al Synthesis, 1985, p. 550 "A new facile synthesis of 11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepines".
Harden et al TIPS, 1986 suppl, 14 "Characteristics of two biochemical responses to stimulation of muscarinic cholinergic receptors".
Harris et al J Med Chem, 1982, 25:855 "Affinity of 10-(4-methylpiperazino)dibenz[b,f]oxepins for clozapine and spiroperidol binding sites in rat brain".
Jaen et al Annual Reeports in Medicinal Chemistry-29 p. 23, (1994) "Recent advances in the design and characterization of muscarinic agonists and antagonists".
Jones et al Life Sciences, 1993, 52:457 "Muscarinic receptor subtypes: modulation of ion channels".
Kaiser et al Neurotransmissions, 1987, vol. III No. 2 "Cholinergic agents".
Klunder et al J Med Chem, 1992, 35:1887 "Novel non-nucleoside inhibitors of HIV-1 reverse transcriptase. tricyclic pyridobenzoxazepinones and dibenzoxazepinones".
de Paulis et al. J Med Chem, 1981, 24(9):1021 "Synthesis of clozapine analogues and their affinity for clozapine and spiroperidol binding sites in rat brain".
Sindelar et al Coll. Czechoslov. Chem. Commun., 1977, 42:2231 "Noncataleptic potential neuroleptics: 2-nitro and 2-hydroxy derivatives of 10-(4-methylpiperzino)-10,11-dihydrodibenzo[b,f]thiepin".
Watson et al Trends Pharmacol Sci suppl 7, 1986, p. 46 "Biochemical and functional basis of putative muscarinic receptor subtypes and its implications".
Rakhit Sumanas
Tehim Ashok
Allelix Biopharmaceuticals Inc.
Datlow Philip I.
LandOfFree
Muscarinic receptor ligands does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Muscarinic receptor ligands, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Muscarinic receptor ligands will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1502101