Muscarinic receptor antagonists

Details Muscarinic receptor antagonists Muscarinic receptor antagonists

1993-01-06

1994-04-12

Lee, Mary C.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514351, 514357, 514438, 514445, 514413, 514450, 514437, 514454, 514618, 514619, 514620, 544336, 544408, 546300, 546334, 549 65, 549 76, 549 12, 549 26, 549354, 549388, 564161, 564162, 564164, 564165, A61K 31495, A61K 3144, C07D24102, C07D33336

Patent

active

053025954

ABSTRACT:
Compounds of the formula I ##STR1## wherein X, Y and v are as defined below, novel intermediates used in their synthesis, and the pharmaceutically acceptable salts of such compounds and intermediates. The compounds of formula I and the novel intermediates used in their synthesis are muscarinic receptor antagonists that are selected for smooth muscle muscarinic sites and are useful in the prevention and treatment of diseases associated with altered motility or tone of smooth muscle, such as irritable bowel syndrome, diverticular disease, urinary incontinence, aesophageal achalasia, and chronic obstructive airways disease.

REFERENCES:
patent: 4335122 (1982-06-01), McFadden et al.
Chemical Abstracts, 70(19), p. 293, abstract no. 87390u (May 12, 1969).
Casy et al., J. Pharm. and Pharmacol, 19, 17-24 (1967).
Gulatieri et al., J. Med. Chem., 28, 1621-28 (1985).
Maffett et al., ".alpha.,.alpha.-Diphenyl-Y-Amino Amides," 4451-7, 79 (1957).

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