Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1999-01-22
2000-08-01
Morris, Patricia L.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
546256, A61K 314439, C07D41714
Patent
active
060967676
ABSTRACT:
A compound of Formula (I): ##STR1## wherein R is a linkage independently selected from (CH.sub.2).sub.12 or (CH.sub.2).sub.4 O.sub.3 ; and acid addition salts, solvates and hydrates thereof. The compounds have unusually high affinity for muscarinic receptors, and exhibit agonist activity useful in the treatment of neurological and other disorders, in which stimulating cholinergic activity is desirable.
REFERENCES:
patent: 5414009 (1995-05-01), Olesen et al.
patent: 5718912 (1998-02-01), Thomspon et al.
Per Sauerberg, Preben H. Olesen, Susanne Nielsen, Svend Treppendahl, Malcolm J. Sheardown, Tage Honore, Charles H. Mitch, John S. Ward, Andrew J. Pike, Frank P. Bymaster, Berry D. Sawyer and Harlan E. Shannon, Novel Functional M.sub.1 Selective Muscarinic Agonists. Synthesis and Structure-ActivityRelationshipsof3-(1,2,5-Thiadiazolyl)-1,2,5,6-tetrahydro -1-methylpyridines, J. Med. Chem. (1992), 35, pp. 2274-2283.
Philip G. Dunbar, Graham J. Durant, Zheng Fang, Yahaya F. Abuh, Afif A. El-Assadi, Dan O. Ngur, Sumudra Periyasamy, Wayne P. Hoss and William S. Messer, Jr., Design, Synthesis, and Neurochemical Evaluation of 5-(3-Alkyl-1,2,4-oxadiazol-5-yl)-1,4,5,6-tetrahydropyrimidines as M.sub.1 Muscarinic Receptor Agonists, J. Med. Chem. (1993), 36, pp. 842-847.
John S. Ward, Leander Merritt, David O. Calligaro, Franklin P. Bymaster, Harlan E. Shannon, Charles H. Mitch, Celia Whitesitt, David Brunsting, Malcolm J. Sheardown, Preben H. Olesen, Michael D.B. Swedberg, Lone Jeppesen, and Per Sauerberg, 1,2,5-Thiadiazole Analogues of Aceclidine as Potent m.sub.1 Muscarinic Agonists, J. Med. Chem. (1998), 41, pp. 379-392.
Per Sauerberg, Lone Jeppesen, Preben H. Olesen, Th.o slashed.ger Rasmussen, Michael D.B. Swedberg, Malcolm J. Sheardown, Anders Fink-Jensen, Christian Thomsen, Henning Th.o slashed.gersen, Karin Rimvall, John S. Ward, David O. Calligaro, Neil W. DeLapp, Frank P. Bymaster and Harlan E. Shannon, Muscarinic Agonists with Antipsychotic-like Activity: Structure-Activity Relationships of 1,2,5-Thiadiazole Analogues with Functional Dopamine Antagonist Activity, J. Med. Chem. (1998), 41, pp. 4378-4384.
Lone Jeppesen, Preben H. Olesen, Lena Hansen, Malcolm J. Sheardown, Christian Thomsen, Th.o slashed.ger Rasmussen, Anders Fink Jensen, Michael S. Christensen, Karin Rimvall, John S. Ward, Celia Whitesitt, David O. Calligaro, Frank P. Bymaster, Neil W. DeLapp, Christian C. Felder, Harlan E. Shannon, and Per Sauerberg, 1,(1,2,5-Thiadiazol-4-yl)-4-azatricyclo[2.2.1.0.sup.2,6 ]heptanes as New Potent Muscarinic M.sub.1 Agonists: Structure-Activity Relationship for 3-Aryl-2-propyn-1-yloxy and 3-Aryl-2-propyn-1-ylthio Derivatives, J. Med. Chem. (1999), 42, pp. 1999-2006.
Messer William S.
Rajeswaran Walajapet G.
Morris Patricia L.
The University of Toledo
LandOfFree
Muscarinic receptor agonists does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Muscarinic receptor agonists, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Muscarinic receptor agonists will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-664397