Muscarinic antagonists

Details Muscarinic antagonists Muscarinic antagonists

1996-08-08

1999-03-30

Grumbling, Matthew V.

Abrasive tool making process, material, or composition

544215, 544180, 544238, 544295, 544315, 544319, 544360, 544284, 544279, 544256, 544267, 544280, 544278, 544261, 544262, 544263, 544264, 544265, 544255, 544249, 544236, 544250, 544254, 546186, 546187, 546188, 546189, C07D40102, C07D40302, C07D40314, C07D40114

Patent

active

058890068

ABSTRACT:
Di-N-substituted piperazine or 1,4 di-substituted piperadine compounds in accordance with formula I (including all isomers, salts, esters, and solvates) ##STR1## wherein R, R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.21, R.sup.27, R.sup.28, X, Y, and Z are as defined herein are muscarinic antagonists useful for treating cognitive disorders such as Alzheimer's disease. Pharmaceutical compositions and methods of preparation are also disclosed. Also disclosed are synergistic combinations of compounds of the above formula with acetylcholinesterase inhibitors.

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