Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Patent
1997-06-26
1999-08-10
Bernhardt, Emily
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
5142358, 514253, 514254, 514255, 544121, 544295, 544360, 544364, 544365, 544376, 544377, 544379, 544398, 544399, 544400, 544403, A61K 31495, A61K 31445, C07D40112, C07D40514
Patent
active
059359587
ABSTRACT:
Di-N-substituted piperazine or 1,4-di-substituted piperidine compounds in accordance with formula I (including all isomers, salts, esters, and solvates) ##STR1## wherein Q, n, R, R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.21, R.sup.27, R.sup.28, X, and Z are as defined herein are muscarinic antagonists useful for treating cognitive disorders such as Alzheimer's disease. Pharmaceutical compositions and methods of preparation are also disclosed. Also disclosed are synergistic combinations with acetyl-cholinesterase inhibitors of compounds capable of enhancing acetylcholine release and having the above formula.
REFERENCES:
patent: 4895841 (1990-01-01), Sugimoto et al.
patent: 5110901 (1992-05-01), Sugimoto et al.
patent: 5691323 (1997-11-01), Thompson et al.
Quirion et al, TIPS pp. 80-84 (Dec. 1989).
Gray et al, TIPS pp. 85-88 (Dec. 1989).
Melchiorre et al, J. Med. Chem. 36 p. 3734 (1993).
Baumgold et al., Eur. J. Pharmacol., 251, (1994) 315-317.
Logermann et al, Brit. J. Pharmacol., 17 (1961), pp. 286-296.
Cheng et al, Biochem. Pharmacol., 22 (1973), pp. 3099-3108.
Watson et al, J. Pharmacol. Exp. Ther., 237 (1986), pp. 411-418.
Sindelar, et al, Collect. Czech Chem. Commun., 54 (8) (1989), pp. 2240-2247.
Evans et al, J. Med. Chem., 27, 9 (1984), pp. 1127-1131.
Chang Wei K.
Dugar Sundeep
Kozlowski Joseph A.
Lowe Derek B.
Bernhardt Emily
Magatti A. W.
Schering Corporation
LandOfFree
Muscarinic antagonists does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Muscarinic antagonists, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Muscarinic antagonists will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1120404