Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1998-11-19
2000-03-14
Dees, Jose' G.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514315, 514317, 546184, 546186, 546187, 546197, 546208, 546214, A61K 31445, C07D21100, C07D21108
Patent
active
060373520
ABSTRACT:
Di-N-substituted piperazine or 1,4 di-substituted piperadine compounds in accordance with formula I (including all isomers, salts, esters, and solvates) ##STR1## wherein R, R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.21, R.sup.27, R.sup.28, X, Y, and Z are as defined herein are muscarinic antagonists useful for treating cognitive disorders such as Alzheimer's disease. Pharmaceutical compositions and methods of preparation are also disclosed. Also disclosed are synergistic combinations of compounds of the above formula or other compounds capable of enhancing acetylcholine release with acetylcholinesterase inhibitors.
REFERENCES:
patent: 2819273 (1958-01-01), Drain et al.
patent: 3852455 (1974-12-01), Carr
patent: 4895841 (1990-01-01), Sugimoto et al.
Baumgold, et al., European Journal of Pharmacology 251 (1994) 315-317.
Doods, et al., Life Sciences, vol. 52, pp. 497-503 (1993).
Eberlein, et al., Trends in Pharmacol Sci Dec. 1989 p 50-54.
Borroni, et al., Biochem Soc. Trans, Aug. 1994, 22(3) p. 755-758.
Logemann, et al., Brit. J. Pharmacol (1961) 17, 286-296.
Wilkerson et al, J. Med. Chem., 36 (20) (1993), p. 2899-2907.
Vidaluc et al, J. Med. Chem., 37 (5) (1994), p. 689-695.
Drukarch et al, Eur. J. Pharmacol., 141 (1-2) (1987), p. 153-157.
Provan et al, Brit. J. Pharmacol., 111 (4) (1994), p. 1103-1110.
Cheng et al, Biochem. Pharmacol., 22 (1973), p. 3099-3108.
Watson et al, J. Pharmacol. Exp. Ther., 237 (1986), p. 411-418.
Protiva et al, Collect. Czech. Chem. Comm., 40, 12 (1975), p. 3904-3923.
Chemical Abstracts, 53, abstract 9254b.
Asberom Theodros
Barnett Allen
Berger Joel G.
Browne Margaret E.
Chackalamannil Samuel
Dees Jos,e G.
Magatti Anita W.
Qazi Sabiha N.
Schering Corporation
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