Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Reexamination Certificate
2007-07-03
2007-07-03
Chang, Celia (Department: 1625)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
C514S321000, C546S198000, C546S202000
Reexamination Certificate
active
10623119
ABSTRACT:
Compounds and methods are provided for the treatment of disease conditions in which modification of cholinergic, especially muscarinic m1, m4, or both m1 and m4, receptor activity has a beneficial effect. In the method, an effective amount of a compound is administered to a patient in need of such treatment.
REFERENCES:
patent: 3412097 (1968-11-01), Gerardus
patent: 3417087 (1968-12-01), Neiss et al.
patent: 4186136 (1980-01-01), Robba et al.
patent: 4458075 (1984-07-01), Davis et al.
patent: 4870085 (1989-09-01), Glaser et al.
patent: 5494908 (1996-02-01), O'Malley et al.
patent: 5580982 (1996-12-01), O'Malley et al.
patent: 5654320 (1997-08-01), Catlow et al.
patent: 5703070 (1997-12-01), Lavielle et al.
patent: 5707798 (1998-01-01), Brann
patent: 5756754 (1998-05-01), O'Malley et al.
patent: 5912132 (1999-06-01), Brann
patent: 5925766 (1999-07-01), O'Malley et al.
patent: 5955281 (1999-09-01), Brann
patent: 6046203 (2000-04-01), O'Malley et al.
patent: 6566364 (2003-05-01), Peglion et al.
patent: 2001/0034352 (2001-10-01), Pelgion et al.
patent: 4039631 (1992-06-01), None
patent: 0091512 (1983-10-01), None
patent: 0511610 (1992-11-01), None
patent: 6511642 (1966-03-01), None
patent: WO 98/04546 (1998-02-01), None
patent: WO 98/20548 (1998-07-01), None
patent: WO 98/57953 (1998-12-01), None
patent: WO 94/12495 (2003-02-01), None
Vitali et al. “Biological properties . . . ” CA 70:37702 (1969).
Moltzen et al. “The use of4-phenylpiperidines . . . ” CA 119:117118 (1993).
Nakazato et al. “Preparation of thiazole . . . ” CA 126:8111(1996).
Exhibit A.
Asahi Chem., 3-aminoindazole derivatives, CA 101:23469 (1983).
Dutta, et al., Highly selective, novel analogs of 4-[2-(diphenylmethoxy)ethyl]-1-benzylpiperidine for the dopamine transporter: effect of different aromatic substitutions on their affinity and selectivity, CA 126:69745 (1997).
Fujimura, et al., Indazole derivatives, CA 87:53273 (1976).
Hanning, et al., Preparation of some derivatives of 5-methyl-indazole-3-carboxylic acid, CA 80:82791 (1973).
Lounasmaa, M., et al., Acid-catalyzed epimerization of indolo[2,3α]quinolizidines. 1-,2- and 3-monosubstituted alkyl derivatives, Tetrahedron, 53(14):5349-5356 (1997).
Lounasmaa, M., et al., Stereochemical course of the modified polonovski reaction and meucuric acetate oxidation in the preparation of 2-substituted 1,2,3,4,6,7,12,12b-octahydroindolo[2,3-α]quinolizines, Tetrahedron, 47(32):6371-6380 (1991).
Lounasmaa, M., et al., Stereoregulation of the c(12b)H-C(2)H relationship in the preparation of 2-substituted 1,2,3,4,6,7,12,12b-octahydroindolo[2,3-α]quinolizines, Tetrahedron, 44(12):3975-3992 (1989).
Minieri, et al., Bactericidal and fungicidal 1-(aminomethyl)indazoles, CA 79:442494 (1973).
Orth, et al., Centrally acting isosteric Mannich bases, CA 70:11473 (1968).
Pavia, et al., “Structure activity . . . ” CA 118:6834 (1992).
Rao, et al., Synthesis and radioprotective activity of .beta.-(3-indazolyl)ethylamine derivatives, CA 108:94460 (1987).
Synthelabo, Preparation of 1-[(hetero)aroyl]-4-(4-imidazolyl)piperidines as serotoninergic receptor antagonists, CA 121:9402 (1994).
Zenitz, et al., 1-indolylglyoxalyl)piperidines, CA 64:67726 (1965).
Sample compounds.
Davis, et al.3-Substituted-1-2-Benzisoxazoles: Novel Antipsychotic Agents, Drug Design and Discovery, vol. 8, No. 3 1992, Harwood Academic Publishers GmbH, pp. 225-240; XP000608016.
Britton, et al. “Structure-Activity Relationships of a Series of Benzothiophenederived NPY Y1 Anatagonists: Optimization of the C-2 Side Chain” Bioorganic & Medicinal Chemistry Letters 9, (1999) 475-480.
Chevolot, et al. “Indoles, XI Synthesis of DI . . . ” CA 84: 31279 (1975).
Anderson Carl-Magnus A.
Friberg Bo Lennart M.
Skjaerbaek Niels
Spalding Tracy A.
Uldam Allan K.
Acadia Pharmaceuticals Inc.
Chang Celia
Knobbe Martens Olson & Bear LLP
LandOfFree
Muscarinic agonists does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Muscarinic agonists, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Muscarinic agonists will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3776286