Drug – bio-affecting and body treating compositions – Immunoglobulin – antiserum – antibody – or antibody fragment,... – Structurally-modified antibody – immunoglobulin – or fragment...
Patent
1991-11-15
1995-12-12
Lacey, David L.
Drug, bio-affecting and body treating compositions
Immunoglobulin, antiserum, antibody, or antibody fragment,...
Structurally-modified antibody, immunoglobulin, or fragment...
4241301, 4241541, 4241441, 4241531, 5303887, 53038873, 53038875, 435 7021, 4351722, 43524027, A61K 3900, C07K 1618, C07K 1628, G01N 3353
Patent
active
054747716
ABSTRACT:
This invention provides a monoclonal antibody which specifically recognizes and forms a complex with a protein located on the surface of activated T cells and thereby inhibits T cell activation of B cells. This invention also provides the monoclonal antibody 5c8 (ATCC Accession No. HB 10916).
This invention provides a human CD4.sup.- T cell leukemia cell line designated D1.1 (ATCC Accession No. CRL 10915) capable of constitutively providing contact-dependent helper function to B cells. This invention also provides an isolated protein from the surface of activated T cells, wherein the protein is necessary for T cell activation of B cells. This invention further provides an isolated, soluble protein from the surface of activated T cells, wherein the protein is necessary for T cell activation of B cells.
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Hodgkin, P. D. et al. Separation of events mediating B cell proliferation and Ig production by using T cell membranes and lymphokines. J. Immunol. 1990; 145(7): 2025-2034 (Exhibit G).
Kubota, E. et al. Role of T cells in the B-cell response: glutaraldehyde-fixed T-helper hybridoma cells synergize with the lymphokine IL-4 to induce B-cell activation and proliferation. Immunology 1991; 72: 40-47 (Exhibit H).
Noelle, R. J. et al. Cognate interactions between helper T cells and B cells. III. Contact-dependent, lymphokine-independent induction of B cell cycle entry by activated helper T cells. J. Immunol. 1989; 143(6): 1807-1814 (Exhibit I).
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Rabin, E. M. et al. B-cell stimulatory factor l activates resting B cells. Proc. Natl. Acad. Sci. USA 1985; 82 2935-2939 (Exhibit K).
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Tohma, S. et al. The role of CD11a/CD18-CD54 interactions in human T cell dependent B cell activation. J. Immunol. 1991; 146(2): 492-499 (Exhibit P).
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Torimoto, Y. et al. Development of a monoclonal antibody, anti-6C2, which is involved in the interaction CD4 T helper cells and activated B cells. J. Immunol. 1991; 146(7): 2176-2184 (Exhibit R).
Chess Leonard
Lederman Seth
Yellin Michael J.
Gambel Phillip
Lacey David L.
The Trustees of Columbia University in the City of New York
White John P.
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