Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives
Reexamination Certificate
2005-05-10
2008-07-15
Helms, Larry R. (Department: 1643)
Organic compounds -- part of the class 532-570 series
Organic compounds
Carbohydrates or derivatives
C424S133100, C514S012200
Reexamination Certificate
active
07399849
ABSTRACT:
The present invention provides a monoclonal anti-Idiotype antibody 11D10 that elicits an immune response against a specific epitope of a high molecular weight mucin of human milk fat globule (HMFG) and a hybridoma that produces 11D10. The hybridoma that produces 11D10 was selected by specific procedures. 11D10 induces an immunological response to HMFG in mice, rabbits, monkeys and patients with advanced HMFG-associated tumors. This invention provides compositions derived from polynucleotide sequences encoding the variable light and/or variable heavy regions of monoclonal anti-idiotype antibody 11D10, as well as polypeptides encoded thereby. The invention also provides compositions which can be used in the detection or treatment of HMFG—associated tumors.
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Defreit
Chatterjee Malaya
Chatterjee Sunil K.
Foon Kenneth A.
Helms Larry R.
Myers, Jr. Richard S.
Natarajan Meera
Sitites & Harbison PLLC
University of Kentucky Research Foundation
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