Multicellular living organisms and unmodified parts thereof and – Nonhuman animal
Patent
1995-11-13
1999-11-16
Chambers, Jasemine C.
Multicellular living organisms and unmodified parts thereof and
Nonhuman animal
424 92, 435325, C12N 500, C12N 510
Patent
active
059861703
ABSTRACT:
A murine model for human ovarian and prostate cancer is provided. The model comprises an immunodeficient mouse containing human primary ovarian or prostate carcinoma tissue implanted within the gonadal fat pad. Methods of using the murine model, for example, to grow tumors and to screen treatments for ovarian and/or prostate cancer are also provided.
REFERENCES:
patent: 5399346 (1995-03-01), Anderson et al.
patent: 5569812 (1996-10-01), Monosov et al.
Xu, Y. et al., Coengrafment of Human Primary Breast Carcinoma & Autologous Immunocompetent Cells in SCID Mice. American Assoc. Cancer Research, Annual Meeting, Mar. 1995.
Sakakibara, T. et al., Engraftment and Growth of Patients' Breast Carcinoma in SCID Mice, San Antonio Breast Cancer Symposium, submitted Jun. 1994.
Bachmann et al. "In vivo versus in vitro assays for assessment of T--and B--cell Functionl," Current Opinion in Immunology, vol. 6 (2):320-326, 1995.
Outzen et al. "Growth of human normal and neoplastic mammary tissues in the cleared mammary fat pad of the nude mouse," J. Nat. Cancer Inst., vol. 55(6): 1461-1466, 1975.
Bennett et al., "Accurate Prediction of Experimental Cancer Chemosensitivity Using the Subrenal Capsule Xenograft Assay," Journal of Surgical Oncology 33:8-13, 1986.
Bumpers et al., "Consistent Hepatic Metastasis of Human Colorectal Cancer in Severe Combined Immunodeficient Mice," Journal of Surgical Research 61:282-288, 1996.
Hagiwara et al., "Milky Spots as the Implantation Site for Malignant Cells in Peritoneal Dissemination in Mice," Cancer Research 53:687-692, 1993.
Niederberger et al., "Differences Between Subcutaneous and Intraperitoneal Forms of Three Human Testicular Teratocarcinomas in Nude Mice," Cancer 61:1571-1578, 1988.
Russell et al., "Bladder Cancer Xenografts: A Model of Tumor Cell Heterogeneity," Cancer Research 46(4):2035-2040, 1986.
Yano et al., "Inhibition of growth of MCF-7 MIII human breast carcinoma in nude mice by treatment with agonists or antagonists of LH-RH," Breast Cancer Research and Treatment 21:35-45, 1992.
Chambers Jasemine C.
Corixa Corporation
Hauda Karen M.
LandOfFree
Murine model for human carcinoma does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Murine model for human carcinoma, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Murine model for human carcinoma will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1326949