Murine hybridoma and antibody binding to CD28 receptor secreted

Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Blood proteins or globulins – e.g. – proteoglycans – platelet...

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53038822, 435334, 435346, C12N 500, C07K 1600

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active

059488930

ABSTRACT:
The invention pertains to a murine hybridoma cell (ATCC HB 11944) that secretes a monoclonal antibody (PV-1) that binds to the CD 28 receptor. The antibody selectively stimulates the production of T-Cell populations to proliferate and expand in the absence of exogenous growth factors and accessory cells.

REFERENCES:
Kaye et al. (1995) J. Cell. Biochem. Supplement O(21A), 171.
Gross et al. (1992) J. Immunol, vol. 149: 380-388.
Baroja et al. (1989) Cell Immunol. vol. 120(1): 205-217.
Harding et al. (1992) Nature (Lond) vol. 356(6370): 607-609.
Johnstone et al. Immunochemistry in Practice. 2nd edition Blackwell Scienic Publications Oxford. 1987 pp. 232,264-266.

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