Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Blood proteins or globulins – e.g. – proteoglycans – platelet...
Patent
1996-01-17
1999-09-07
Eisenschenk, Frank C.
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Blood proteins or globulins, e.g., proteoglycans, platelet...
53038822, 435334, 435346, C12N 500, C07K 1600
Patent
active
059488930
ABSTRACT:
The invention pertains to a murine hybridoma cell (ATCC HB 11944) that secretes a monoclonal antibody (PV-1) that binds to the CD 28 receptor. The antibody selectively stimulates the production of T-Cell populations to proliferate and expand in the absence of exogenous growth factors and accessory cells.
REFERENCES:
Kaye et al. (1995) J. Cell. Biochem. Supplement O(21A), 171.
Gross et al. (1992) J. Immunol, vol. 149: 380-388.
Baroja et al. (1989) Cell Immunol. vol. 120(1): 205-217.
Harding et al. (1992) Nature (Lond) vol. 356(6370): 607-609.
Johnstone et al. Immunochemistry in Practice. 2nd edition Blackwell Scienic Publications Oxford. 1987 pp. 232,264-266.
Craighead Nancy
June Carl H.
Eisenschenk Frank C.
Nolan Patrick J.
Spevack A. David
The United States of America as represented by the Secretary of
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