Chemistry: molecular biology and microbiology – Animal cell – per se ; composition thereof; process of... – Animal cell – per se – expressing immunoglobulin – antibody – or...
Patent
1997-01-21
1998-12-29
Feisee, Lila
Chemistry: molecular biology and microbiology
Animal cell, per se ; composition thereof; process of...
Animal cell, per se, expressing immunoglobulin, antibody, or...
435343, 4353431, 435326, 435328, 435346, 435358, 435334, 5303871, 5303873, 5303881, 5303882, 53038822, 5303887, 53038873, 53038875, C07K 1618, C07K 1628, C12N 512
Patent
active
058540709
ABSTRACT:
Disclosed are methods for the alleviation of symptoms associated with inflammatory disease states, and more particularly to the inhibition of inflammatory processes associated with the multiple sclerosis disease, by administering a pharmaceutically effective amount of antibody substance immunologically reactive with the common .beta. chain (CD18) of human leukocyte integrins and/or competes with mAb 60.3 for binding to human LFA-1.
REFERENCES:
patent: 4797277 (1989-01-01), Arfors
Alvord, JC Koetsier, editor; "Disseminated Encephalomyelitis: Its Variations in Form and Their Relationships to Other Diseases of the Nervous System", Handbook of Clinical Neurol., 3(47):467-502, Koetsier (ed.); Amsterdam; Elsevier Science Publishers BV (1985).
Arfors et al., "A Monoclonal Antibody to the Membrane Glycoprotein Complex CD18 Inhibits Polymorphonuclear Luekocyte Accumulation and Plasma Leakage In Vivo", Bloo, 60:338-340 (1987).
Beatty et al., "Definition of a Common Leukocyte Cell-Surface Antigen (Lp95-150) Associated with Diverse Cell-Mediated Immune Functions," J. Immunol., 131:2913-2918 (1983).
Bohnsack et al., "Human Neutrophil Adherence to Laminin In Vitro", J. Exp. Med., 171:1221-1237 (1990).
Cannella et al., "Anti-Adhesion Molecule Therapy in Experimental Autoimmune Encephalomyelitis (EAE)", J. Neuropathol. Exp. Neurol., 51:382 (May 1992).
Carter et al., "Humanization of an Anti-p185.sup.HER2 Antibody for Human Cancer Therapy", Proc. Nat'l Acad. Sci.(USA), 89:4285-4289 (1992).
Co et al., "Chimeric and Humanized Antibodies with Specificity for the CD33 Antigen.sup.1 .sub.", J. Immunol., 148:1149-1154 (1992).
Co et al., "Humanized Antibodies for Antiviral Therapy", Proc. Nat'l. Acad. Sci. (USA), 88:2869-2873 (1991).
Doerschuk et al., "CD18-Dependent and -Independent Mechanisms of Neutrophil Emigration in the Pulmonary and Systemic Microcirculation of Rabbits", J. Immunol., 144:2327-2333 (1990).
Goding, Monoclonal Antibodies: Principles and Practice, 2d Ed., pp. 241-280, Academic Press, New York (1986).
Gorman et al., "Reshaping a Therapeutic CD4 Antibody", Proc. Nat'l Acad. Sci. (USA), 88:4181-4185 (1991).
Harlan et al., "The Role of Neutrophil Membrane Glycoprotein GP-150 in Neutrophil Adherene to Endothelium In Vitro", Blook, 66:167-178 (1985).
Hauser et al., "Immunoregulatory T-Cells and Lymphocytotoxic Antibodies in Active Multiple Sclerosis: Weekly Analysis Over a Six-Month Period", Ann Neurol., 13:418-425 (1983).
Hernandez et al., "Role of Neutrophils in Ischemia-Reperfusion-Induced Microvascular Injury", Am. J. Physiol., 253:H699 (1987).
Hildreth et al., "Involvement of a Leukocyte Adhesion Receptor (LFA-1) in HIV-Induced Suncytium Formation", Science, 244:1075-1083 (1989).
Hynes, "Integrins: A Family of Cell Surface Receptors", Cell, 48:549-554 (1987).
Jutila et al., "Inflammation-Induced Endothelial Cell Adhesion to Lymphocytes, Neutrophils, and Monocytes", Transplantation, 48:727-731 (1989).
Kettleborough et al., "Humanization of a Mouse Monoclonal Antibody by CDR-grafting: The Improtance of Framework Residues on Loop Conformation", Protein Engineering, 4(7):773-783 (1991).
Kil, "Block-Face Application of a 7:3 Propylene Glycol-Water Mixture to facilitate Cutting of Large Frozen Sections", Stain Technology, 47:271 (1972).
Kirkham et al., "Immunoglobulin V.sub.H clan and family identity predicts variable domain structure and may influence antigen binding", EMBO J., 11:603-609 (1992).
Luscinskas et al., "Endothelial-Leukocyte Adhesion Molecule-1 Dependent and Leukocyte (CD11/CD18)-Dependent Mechanisms Contribute to Polymorphonuclear Leukocyte Adhesion to Cytokine-Activated Human Vascular Endothelium", J. Immunol., 142:2257-2263 (1989).
Maeda et al., "Construction of Reshaped Human Antibodies with HIV-Neutralizing Activity", Hum. Antibod. Hybridomas, 2:124-134 (1991).
Price et al., "In Vivo Inhibition of Neutrophil Function in the Rabbit Using Monoclonal Antibody to CD18", J. Immunol., 139:4174-4177 (1987).
Prineas et al., "Macrphages, Lymphocytes, and Plasma Cells in the Perivascular Compartment in Chronic Multiple Sclerosis", Lab. Invest., 38:409-421 (1978).
Queen et al., "A Humanized Antibody That Binds to the Interleukin 2 Receptor", Proc. Nat'l Acad. Sci. (USA), 86:10029-10033 (1989).
Racke et al., "Modification of Experimental Allergic Encephalomyelitis by Administration of Antibodies", Journal of Cellular Biochemistry, 17A:355 (1993).
Raine et al., "Homing to Central Nervous System Vasculature by Antigen-Specific Lymphocytes", Lab Investigations, 63(4):476-489 (1990).
Rose et al., "In Vivo Administration of Anti-CD4 Monoclonal Antibody Prolongs Survival in Longtailed Macaques with Experimental Allergic Encephalomyelities", Clin. Immunol. Immunopathol., 45:405-423 (1987).
Rose et al., "Magnetic Resonance Imaging and Peripheral Blood Abnormalities in Experimental Allergic Encephalomyelities", Biomed. and Pharmacother., 43:347-353 (1989).
Rose et al., "Remitting-Relapsing EAE in Nonhuman Primates: A Valid Model of Multiple Sclerosis", Clin. Immunol. Immunopathol., 59:1-15 (1991).
Rose et al., "Fluctuations of T-and B-Cell Subsets in Basic Protein-Induced Experimental Allergic Encephalomyelitis (EAE) in Long-Tailed Macaques", Clin. Immunol. Immunopathol., 44:93-106 (1987).
Sanchez-Madrid et al., "Mapping of Antigenic and Functional Epitopes on the .alpha.-and .beta.-Subunits of Two Related Mouse Glycoproteins Involved in Cell Interactions LFA-1 and MAC-1*", J. Exp. Med., 158:586-602 (1983).
Sanchez-Madrid et al., "A Human Leukocyte Differentiation Antigen Family with Distinct .alpha.-Subunits and a Common .beta.-Subunit: The Lymphocyte Function-Associated Antigen (LFA-1), the C3bi Complement Receptor (OKMI/Mac-1), and the p150,95 Molecule", J. Exp. Med., 158:1785-1803 (1983).
Shaw et al., "Chronic Remitting-Relapsing Experimental Allergic Encephalomyelitis Induced in Monkeys with Homologous Myelin Basic Protein", Ann Neurol., 24:738-748 (1988).
Shaw et al., "Treatment of Experimental Allergic Encephalomyelitis in Monkeys", International Symposium on the Aetiology and Pathogenesis of the Demyelinating Diseases, Sep. 1973, Kyoto.
Simonsen and Levinson, "Isolation and expression of an altered mouse dihydrofolate reductase cDNA", Proc. Nat'l. Acad. Sci. USA, 80:2495-2499 (1983).
Snyderman et al., "Molecular and Cellular Mechanisms of Leukocyte Chemotaxis", Science, 213:830-837 (1981).
Springer et al., "Adhesion Receptors of the Immune System", Nature, 346:425-434 (1990).
Tempest et al., "Reshaping a Human Monoclonal Antibody to Inhibit Human Respiratory Syncytial Virus Infection In Vivo", Bio/Technology, 9:266-271 (1991).
Thomas et al., "Differential Effects of Intravenous Anaesthetic Agents on Cell-Mediated Immunity in the Rhesus Monkey", Clin. Exp. Immunol., 47:457-466 (1982).
Traugott et al., "Chronic Relapsing Experimental Allergic Encephalomyelitis: Identification and Dynamics of T and B Cells Within the Central Nervous System", Cell. Immunol., 68:261-275 (1982).
Urlaub et al., "Isolation of Chinese Hamster Cell Mutants Deficient in Dihydrofolate reductase activity," Proc. Nat'l Acad. Sci. USA, 77:4216-4220 (1980).
Urlaub et al., "Deletion of the Diploid Dihydrofolate Reductase Locus from Cultured Mammalian Cells", Cell, 33:405-412 (1983).
Vedder et al., "A Monoclonal Antibody to the Adherence-Promoting Leukocyte Glycoprotein, CD18, Reduces Organ Injury and Improves Survival from Hemorrhagic Shock and Resuscitation in Rabbits", J. Clin. Investo., 81:939 (1988).
Wall et al., "Effects of Ketamine Anaesthesia, Stress and Repeated Bleeding on the Haematology of Vervet Monkeys", Lab Animals, 19:138-144 (1985).
Weiner, Howard L. M.D. et al., "Immunotherapy of Multiple Sclerosis", Ann Neurol., 23:211-222 (1988).
Welsh et al., "Augmentation of Adoptively Transferred Experimental Allergic Encephalomyelitis by Administration of a Monoclonal Antibody Specific for LFA-1.alpha.", J. Neuroimmunology, 43:161-168 (1993).
Wright et al., "Identification of the C3bi Receptor of Human Monocytes and Macrophages by Using Monoclonal Antibodies", Proc. Nat'l. Acad. Sci. (USA), 80:5699-5703 (198
Board of Regents of the University of Washington
Feisee Lila
Gambel Phillip
ICOS Corporation
LandOfFree
Murine and humanizer 23F2G antibodies and cell lines expressing does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Murine and humanizer 23F2G antibodies and cell lines expressing , we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Murine and humanizer 23F2G antibodies and cell lines expressing will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1423816