Chemistry: molecular biology and microbiology – Enzyme – proenzyme; compositions thereof; process for...
Patent
1999-08-30
2000-08-15
Achutamurthy, Ponnathapu
Chemistry: molecular biology and microbiology
Enzyme , proenzyme; compositions thereof; process for...
435 697, 435193, C12N 900
Patent
active
061035076
ABSTRACT:
The invention provides MurE polypeptides and polynucleotides encoding MurE polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing MurE polypeptides to screen for antibacterial compounds.
REFERENCES:
Ornelas-Soares et al. Journal of Biological Chemistry, Nov. 4, 1994, vol. 269, No. 44, pp. 27246-27250.
De Lencastre et al. Antimicrobial Agents and Chemotherapy, Nov. 1, 1994, vol. 38, No. 11, pp. 2590-2598.
Ludovice et al. Microb Drug Resist. Jun. 1, 1998 vol. 4, vol. 2, pp. 85-90.
Daniel, et. al., SwissProt Submission, Accession No. Q03523, Direct Submission. No Date Provided.
Daniel, et. al., "DNA sequence of the murE-murD region of Bacillus subtilis 168." Journal of General Microbiology, vol. 139, pp. 361-370, (1993).
Daniel, et. al., "The Bacillus subtilis spo V D Gene encodes a Mother-cell-specific Penicillin-binding Protein Required for Spore Morphogenesis." Journal of Molecular Biology, vol. 235, pp. 209-220, (1994).
Shilling Lisa Kathleen
Wallis Nicola Gail
Zabierowski Susan
Achutamurthy Ponnathapu
Deibert Thomas S.
Gimmi Edward R.
King William T.
Mayhew Bradley S.
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