MurE

Details MurE MurE

1997-12-10

2000-01-11

Achutamurthy, Ponnathapu

Chemistry: molecular biology and microbiology

Enzyme , proenzyme; compositions thereof; process for...

4353201, 4352523, 43525233, 536 232, C12N 900, C12N 1552, C12N 1500

Patent

active

060134976

ABSTRACT:
The invention provides MurE polypeptides and polynucleotides encoding MurE polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing MurE polypeptides to screen for antibacterial compounds.

REFERENCES:
patent: 5712108 (1998-01-01), Peery et al.
Ornelas-Soares et al. Journal of Biological Chemistry, vol. 269, No. 44, pp. 27246-27250, Nov. 4, 1994.
De Lencastre et al. Antimicrobial Agents and Chemotherapy, vol.38, No. 11, pp. 2590-2598, Nov. 1, 1994.
George et al, "Current methods in sequence comparison and analysis," in Macromolecular Sequencing and Synthesis, Selected Methods and Applications, 1988, D.H. Schlesinger (ed.), Alan R. Liss, Inc., New York, NY, pp. 127-149.
Barton, "Protein sequence alignment and database scanning," in Protein Structure Prediction, A Practical Approach, 1996 IRL Press at Oxford University Press, Oxford, UK, pp. 31-63.
Ludovice et al. Microb Drug Resist. vol. 4, vol. 2, pp. 85-90, Jun. 1, 1998.
Ludovice et al., "Molecular Cloning and DNA Sequencing of the Staphylococcus aureus UDP-N-Acetylmurayl Tripeptide Synthetase (murE) Gene, Essential for the Optimal Expression of Methicillin Resistance.", Microbial Drug Resistance, vol. 4, No. 2, pp. 85-90, (1998).
Daniel, et al., "DNA Sequence of the murE-murD Region of Bacillus subtilis 168.", Journal of General Microbiology, vol. 139, pp. 361-370, (1993).
Michaud, et al., "Over-production, purification and properties of the uridine-diphosphate-N-acetylmuramoyl-L-alanyl-D-glutamate: meso-2,6-diaminopimelate ligase from Escherichia coli", Eur. J. Biochem. 194, 853-861 (1990), FEBS 1990.
Daniel, et. al., SwissProt Submission, Accession No. Q03523, Direct Submission. (No Date Provided).
Daniel, et. al., "DNA sequence of the murE-murD region of Bacillus subtilis 168." Journal of General Microbiology, vol. 139, pp. 361-370, (1993).
Daniel, et. al., "The Bacillus subtilis spo V D Gene encodes a Mother-cell-specific Penicillin-binding Protein Required for Spore Morphogenesis." Journal of Molecular Biology, vol. 235, pp. 209-220, (1994).

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