Mure

Details Mure Mure

1999-09-17

2000-09-19

Stole, Einar

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Fusion protein or fusion polypeptide

424 945, 4241851, 4241901, 435 4, 435183, A61K 3900, A61K 3851, A61K 3902, C12Q 100, C12N 900

Patent

active

061207713

ABSTRACT:
The invention provides MurE polypeptides and DNA (RNA) encoding MurE polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing MurE polypeptides to screen for antibacterial compounds.

REFERENCES:
patent: 5712108 (1998-01-01), Peery et al.
patent: 5821096 (1998-10-01), Peery et al.
Daniel, et al., "DNA Sequence of the murE-murD Region of Bacillus subtilis 168", Journal of General Microbiology, vol. 139, pp. 361-370, Jan. 1, 1993.
Van Assche, et al., "Synthesis and Antibacterial Evaluation of Phosphonic Acid Analogues of Diaminopimelic Acid", European Journal of Medicinal Chemistry, vol. 26, pp. 505-515, (page 507, right-hand column, line 20--line 48), (1991).
European Search Report completed Aug. 27, 1999 from corresponding European Application No. 98203300.3, filed Sep. 29, 1998.
Daniel, et. al . . . , GenBank Submission, Accession No.P46343, "(EC 6.32.13)(UDP-N-acetylmuramyl-Tripeptide.".
Michaud, et. al., "Over-production, purification and properties of the uridine-disulfate-N-acetylmuramoyl-L-alanyl-D-glutamate: meso-2,6-diaminopimelate ligase from Escherichia coli." Eur. J. Biochem., vol. 194, pp. 853-861, (1990).
Itaya, et. al., "A new micromethod for the colorimetric determination of inorganic phosphate." Clinica Chimica Acta, vol. 14, pp. 361-366, (1966).

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