Muramylpeptide-glycoprotein immunostimulant derivatives, their p

Details Muramylpeptide-glycoprotein immunostimulant derivatives, their p Muramylpeptide-glycoprotein immunostimulant derivatives, their p

1984-06-04

1989-01-31

Schain, Howard E.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

424 858, 424 88, 424 89, 530322, 530395, 530397, C07K 1514, C07K 900, A61K 3702, A61K 4505

Patent

active

048015784

ABSTRACT:
Macromolecular conjugates of muramylpeptides useful as a stimulant of the cellular immune systems have the formula (R--X).sub.m --(LAM) wherein R is an N-acetylmuramylpeptidyl group or a derivative thereof; (LAM) is a neoglycoprotein having affinity for macrophages or monocytes, consisting of a protein covalently substituted by more than five glycidic chains, each having at least five osidic units, X is a covalent bond between a functional group of the peptidic part of R and a functional group of (LAM) or X is the residue of a conventional bifunctional coupling agent capable of bonding to R and (LAM) by formation of covalent bonds; and m is a number greater than or equal to 1.

REFERENCES:
patent: 4235771 (1980-11-01), Adam et al.
patent: 4314998 (1982-02-01), Yamamura et al.
patent: 4317771 (1982-03-01), Shiba et al.
patent: 4395399 (1983-07-01), Ovchinnikov et al.
patent: 4401659 (1983-08-01), Le Francier et al.
patent: 4446128 (1984-05-01), Baschang et al.
patent: 4639512 (1987-01-01), Audibert et al.
Nature, 285, p. 66 (1980), Goldstein et al.

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