Muramylpeptide active ester derivatives

Chemistry: natural resins or derivatives; peptides or proteins; – Peptides of 3 to 100 amino acid residues – Tripeptides – e.g. – tripeptide thyroliberin – etc.

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Details

536 53, A61K 3700, A61K 3702

Patent

active

046721061

ABSTRACT:
Muramylpeptide active ester derivatives represented by the formula: ##STR1## wherein R.sub.1 represents a hydrogen atom or a fatty acid residue having from 2 to 10 carbon atoms; --COR.sub.2 represents an active ester group; R.sub.3 represents a fatty acid residue having from 1 to 10 carbon atoms; X represents an alanine, N-methylalanine or valine residue; "Acyl" represents a fatty acid residue having from 2 to 6 carbon atoms; and n represents an integer of from 1 to 6. These compounds are applicable as haptens for the immunotherapy and exhibit antitumor activity.

REFERENCES:
patent: 4369178 (1983-01-01), Yamamura et al.
patent: 4406889 (1983-09-01), Hartmann et al.
patent: 4548923 (1985-10-01), Hartmann et al.

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