Muramyldipeptide derivatives

Details Muramyldipeptide derivatives Muramyldipeptide derivatives

1980-06-23

1982-03-02

Hazel, Blondel

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

424177, 424 88, C07C10352, A61K 3900

Patent

active

043177719

ABSTRACT:
Muramyldipeptide derivatives of the formula (I): ##STR1## wherein X represents an amino acid residue such as of L-alanine, L-serine, L-valine, glycine, etc., and Y represents a group ##STR2## wherein R.sub.1 represents a hydrogen atom, an alkyl group of 1 to 6 carbon atoms, a carboxamide group or a carboxyl group, n represents an integer of 1 to 6, A represents a straight or branched chain, saturated or unsaturated aliphatic hydrocarbon residue of 7 to 30 carbon atoms, and "Acyl" means an acyl group of an aliphatic carboxylic acid having 2 to 6 carbon atoms. These compounds have excellent adjuvant activity and/or prophylactic and therapeutic effects against microbial infections.

REFERENCES:
patent: 4220637 (1980-09-01), Audibert et al.
Derwent Abstracts No. 41683, Belgium Pat. No. 849214, 1977.
Chedid, L., et al., Proc. Natl. Acad. Sci., vol. 74, pp. 2089-2093, 1977.

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