Drug – bio-affecting and body treating compositions – Immunoglobulin – antiserum – antibody – or antibody fragment,... – Reduced antigenicity – reduced ability to bind complement – or...
Patent
1980-01-14
1983-08-30
Phillips, Delbert R.
Drug, bio-affecting and body treating compositions
Immunoglobulin, antiserum, antibody, or antibody fragment,...
Reduced antigenicity, reduced ability to bind complement, or...
2601125R, A61K 3700, C07C10352
Patent
active
044016590
ABSTRACT:
A polymer of peptidic type formed by a chain formed from aminoacyl residues preferably derived of at least one of the amino-acid residues selected from the class consisting of .alpha.,.gamma.-diaminobutyric acid, ornithine, lysine, homo-lysine, of which the lateral amino functions portionally carry peptide branches of which the aminoacyl residues are preferably derived of those selected from the class consisting of alanine, glycine, .alpha.-aminobutyric acid, valine, leucine and proline, the above-said peptide polymer having an average molecular weight comprised between about 50,000 and 250,000, and to which are bound covalently, muramyl-peptide units of which the two first aminoacid residues bound to the muramyl group are stereoisomers of the D series, the second aminoacid residue having the structure of the glutamic acid.
This product is useful as anti-infectious agent.
REFERENCES:
patent: 4082735 (1978-04-01), Jones et al.
patent: 4082736 (1978-04-01), Jones et al.
patent: 4094971 (1978-06-01), Chedid et al.
Lefrancier, et al., Chem. Abstr. 93, (1980) 95663a.
Chedid, et al., Chem. Abstr. 91, (1971) 68444g.
Yamamura, et al., Chem. Abstr. 93, (1980) 186796n.
Azuma, et al., Infection Immunity, 1976, 18-27, vol. 14.
Kotani, et al., Biken Journal 20, (1977) 5-10, 95-103.
Yamamura, et al., Gann 67, 867-877 (1976).
Audibert, et al., Cellular Immunology 21, 243-249 (1976).
Chedid, et al., Proc. Nat'l. Acad. Sci. 74, 1977, 2089-2093.
Kusumoto, et al., Tetrahedron Letters, 47, 1976, 4287-4290.
Yamamura, et al., Proc. Japan Acad. 52, 1976, 58-61.
Kotani, et al., Biken Journal 18, (1975) 105-111.
Bergey's Manual of "Determinative Bacteriology", p. 347.
Adam, et al., Biochem. and Biophys. Res. Commun. 72, 1976, pp. 339-346.
Audibert Francoise
Chedid Louis
Choay Jean
Lederer Edgar
Lefrancier Pierre
Agence National de Valorisation de la Recherche (ANVAR)
Phillips Delbert R.
LandOfFree
Muramyl-peptides fixed to peptide-polymers and pharmaceutical co does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Muramyl-peptides fixed to peptide-polymers and pharmaceutical co, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Muramyl-peptides fixed to peptide-polymers and pharmaceutical co will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-905585