Muramyl peptide derivatives and use thereof

Details Muramyl peptide derivatives and use thereof Muramyl peptide derivatives and use thereof

1988-11-17

1990-01-23

Lee, Lester L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

530322, 424 88, 424 89, A61K 3702, C07K 900

Patent

active

048958352

ABSTRACT:
Muramyl peptide derivatives having the formula (I) ##STR1## wherein R.sub.3 is a long chain acyloxyacyl group, R.sub.1 is hydrogen or hydroxy mercapto, acyloxy or acylthio group, R.sub.2 is hydrogen or alkyl group and R.sub.4 is acyl, which are useful as immunomodulators.

REFERENCES:
patent: 4101536 (1978-07-01), Yamamura et al.
patent: 4315913 (1982-02-01), Durette
patent: 4323559 (1982-04-01), Audibert et al.
patent: 4430265 (1984-02-01), Yamamura et al.
patent: 4780313 (1988-10-01), Koichiro et al.
Kotani et al., Yakugaku Zasshi, Immunopharmacological Activities of Bacterial Cell Walls and Related Synthetic Compounds (Muramyl Peptides), 103(1), pp. 1-27 (1983).
Derguini et al., A Versatile Synthesis of Retinoids Via Condensation of the Side-Chain to Cyclic Ketones, Tetrahedron Letters, 51, pp. 4899-4902 (1979).
Matsumoto et al., Anti-Infectious Activity of the Synthetic Muramyl Dipeptide Analogue MDP.Lys (L18), "Immunostimulants", pp. 79-97, Japan Sci. Soc. Press, Tokyo, 1987.

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