Muramyl peptide derivatives and immunoregulating compositions co

Details Muramyl peptide derivatives and immunoregulating compositions co Muramyl peptide derivatives and immunoregulating compositions co

1990-02-26

1991-12-24

Page, Thurman K.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 19, 514885, 530322, 424 88, 424 89, C07K 900, C07K 506, A61K 3912, A61K 3702

Patent

active

050752871

ABSTRACT:
Muramyl peptide derivatives of the formula: ##STR1## wherein "Ala" is ##STR2## "isoGln" is ##STR3## R.sup.1 is R.sub.3 O-- or ##STR4## (k is an integer from 8 to 12; q is an integer from 10 to 22) or R.sub.3 is ##STR5## (m is an integer from 11 to 17; n is an integer from 11 to 17)]; and R.sub.2 is hydrogen atom or --CO--(CH.sub.2).sub.p --CH.sub.3 (p is an integer from 8 to 22); which act on in vivo immunomechanism of human beings and livestock (in particular cells relevant immune responses) and are useful as imminoregulating agents.

REFERENCES:
patent: 4895835 (1990-01-01), Hasegawa
Japanese Published Unexamined Patent Appln. No. 172399/1983.
Japanese Published Unexamined Patent Appln. No. 20297/1984.
Japanese Published Unexamined Patent Appln. No. 275299/1986.
Saishin Igaku, 43, No. 6, pp. 1268-1276 (1988).
Kusumoto et al., Tetrahedion Letters, No. 49, "Synthesis of Long Chain Fatty Acid Esters of N-Acetylmuramyl-L-Alanyl-D-Isoglutamine in Relation to Antitumor Activity", pp. 4899-4902 (1978).
K. Matsumoto et al., Immunostimulants Now and Tomorrow, pp. 79-97 (1987).

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