Muramyl dipeptide derivatives

Details Muramyl dipeptide derivatives Muramyl dipeptide derivatives

1990-06-27

1993-05-11

Lee, Lester L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 18, 530322, 530331, 536 53, A61K 3702, C07K 900

Patent

active

052100723

ABSTRACT:
The 3-O-[N-acetylmuramyl-D-isoglutaminyl]-1,2-di-O-palmitoyl-sn-glycerol derivative of formula I ##STR1## wherein the carbon atom marked with an asterisk * has the R or, respectively, the S configuration, possesses interesting pharmacological, in particular immunomodulating properties. It is particularly useful as an immunomodulant, as an adjuvant in vaccines and as a suppressing agent for IgE formation in e.g. type I allergies and atopical dermatitises.
It is obtained by deprotection of a corresponding compound having one or more hydroxy group(s) in protected form.

REFERENCES:
patent: 4235871 (1980-11-01), Papahadjopoulos et al.
patent: 4315913 (1982-02-01), Durette
patent: 4396607 (1983-08-01), Lefrancier et al.
patent: 4731210 (1988-03-01), Weder et al.
patent: 4897308 (1990-01-01), Vanderberghe et al.
patent: 4939122 (1990-07-01), Phillips et al.
Mehta et al., "Uptake of Liposomes and Liposome Encapsulated Muramyl Dipeptide by Human Peripheral Blood Monocytes", RES: Journal of Reticuloendothelial Society 32:155-164 (1982).
Phillips et al., "Anti Infectious Activity of Liposomal MDP", Infection & Immunity Jun. 1987, pp. 1426-1430.

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