Mur D inhibiting compounds, compositions containing such compoun

Details Mur D inhibiting compounds, compositions containing such compoun Mur D inhibiting compounds, compositions containing such compoun

1998-03-11

2000-02-29

Kight, John

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514460, 549216, 549217, 549218, 549219, 549417, 549418420-, H01N 4316, C07F 928, C07D31506

Patent

active

060309962

ABSTRACT:
The present invention addresses compounds which inhibit Mur D. The compounds are represented by structural formula 1: ##STR1## wherein: X represents OH, OC.sub.1-6 alkyl, O-aryl, O-Har, uridinyl, 5-iodouridinyl or O--Y.sup.+, wherein Y.sup.+ represents a charge balancing group; R.sup.1 and R.sup.2 independently represent H or C.sub.1-6 alkyl, or R.sup.1 and R.sup.2 taken together represent C.sub.1-6 alkylene unsubstituted or substituted with from 1-2 aryl or Har groups; W represents H, aryl, C.sub.1-6 alkyl or a charge balancing group; each M independently represents a member selected from the group consisting of: H, a charge balancing group and a protecting group.
Salts and hydrates thereof are included.
Also included are pharmaceutical compositions and methods of treatment.

REFERENCES:
patent: 4650862 (1987-03-01), Imamura et al.
T. D. Bugg and C. T. Walsh, Natural Products Report; pp. 199-215, (1992).
S. M. Berge et al., J. Pharm. Sci, 66(1), pp. 1-19 (1977).
E. K. Baylis et al, J. Chem So. Perkins Trans., I, pp. 2845-2853 (1984).

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