Multizone analytical element and method for analyte determinatio

Details Multizone analytical element and method for analyte determinatio Multizone analytical element and method for analyte determinatio

1984-04-16

1985-10-15

Turk, Arnold

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving transferase

422 56, 422 57, 435 26, 435805, 436170, 436175, C12Q 132, C12Q 148, G01N 3352

Patent

active

045474605

ABSTRACT:
A multizone analytical element for the determination of an analyte in an aqueous liquid comprises a registration zone and a porous spreading zone to receive and transport the aqueous liquid. The spreading zone contains a nonpolymeric quaternary ammonium compound represented by either of the structures: ##STR1## wherein represents a single or double bond; R.sub.1, R.sub.2, R.sub.3 and R.sub.4 are independently alkyl; aryl; cycloalkyl; or alkaryl; provided that R.sub.1, R.sub.2, R.sub.3 and R.sub.4 together comprise at least 12 carbon atoms; or R.sub.1 and R.sub.2 taken together with the nitrogen atom, form a quaternary 5- to 16-membered heterocyclic ring; or R.sub.1, R.sub.2 and R.sub.3 taken together with the nitrogen atom, form a quaternary 5- to 16-membered heterocyclic ring; and X.sup.- is a monovalent anion. This element is particularly useful for rate determinations of enzymes, such as alanine aminotransferase and aspartate aminotransferase, in liquids containing bilirubin or protein which may interfere with the accuracy of the assay.

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