Multivescular liposomes with controlled release of encapsulated

Details Multivescular liposomes with controlled release of encapsulated Multivescular liposomes with controlled release of encapsulated

1997-05-23

1998-06-16

Kishore, Gollamudi S.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Liposomes

424 121, 424 9321, 424 951, 424417, 264 41, 264 43, 264 46, 436829, 935 54, A61K 9127

Patent

active

057666270

ABSTRACT:
A multivesicular liposome composition containing at least one acid other than a hydrohalic acid and at least one biologically active substance, the vesicles having defined size distribution, adjustable average size, internal chamber size and number, provides a controlled release rate of the biologically active substance from the composition. A process for making the composition features addition of a non-hydrohalic acid effective to sustain and control the rate of release of an encapsulated biologically active substance from the vesicles at therapeutic levels in vivo.

REFERENCES:
patent: 4814270 (1989-03-01), Piran
patent: 4975282 (1990-12-01), Cullis
patent: 5334381 (1994-08-01), Unger et al.
patent: 5334391 (1994-08-01), Clark et al.
Crommelin, Internat. J. Pharmaceutics, 16, p. 79, 1989.
Spector et al., "Topology of Multivesicular Liposomes, a Model Biliquid Foam", Langmuir 12:4704-4708, (1996).

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