Multivalent macrolide antibiotics

Details Multivalent macrolide antibiotics Multivalent macrolide antibiotics

2007-02-20

2007-02-20

Shibuya, Mark (Department: 1639)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

C514S183000, C514S228800, C514S231200, C514S231500, C514S235500, C514S236800, C514S359000, C514S374000, C514S376000

Reexamination Certificate

active

10330381

ABSTRACT:
Disclosed are multibinding compounds which include macrolide antibiotics, aminoglycosides, lincosamides, oxazolidinones, streptoramins, tetracycline and/or other compounds which bind to bacterial ribosomal RNA and/or to one or more proteins involved in ribosomal protein synthesis in the bacterium, which are useful in treating bacterial infections. The compounds adversely affect protein expression and have an antibacterial effect. The multibinding compounds of this invention containing from 2 to 10 ligands covalently attached to one or more linkers. Each ligand is macrolide antibiotic, aminoglycoside, lincosamide, oxazolidinone, streptogramin, tetracycline or other compound which binds to bacterial ribosomal RNA and/or one or more proteins involved in ribosomal protein synthesis in the bacterium.

REFERENCES:
patent: 5693791 (1997-12-01), Truett
patent: 6437119 (2002-08-01), Truett
patent: WO 95/07271 (1995-03-01), None
Zurenko et al.; Exp. Opin. Invest. Drugs (1997) vol. 6 (2) 151-158.
Ahonkhai et al., “In Vitro Activity of U-57930E, a New Clindamycin Analog, Against Aerobic Gram-Positive Bacteria”, Antimicrobial Agents and Chemotherapy, vol. 21, No. 6, pp. 902-905. (Jun. 1982).
Brickner et al., “Synthesis and Antibacterial Activity of U-100592 and U-100766. Two Oxazolidinone Antibacterial Agents for the Potential Treatment of Multidrug-Resistant Gram-Positive Bacterial Infections”, J. Med. Chem, vol. 39, pp. 673-679 (1996).
Portoghese, “The Role of Concepts in Structure-Activity Relationship Studies of Opioid Ligans”, J. Med. Chem., vol. 35, No. 11, pp. 1927-1937 (May 29, 1992).
Rao et al., “Tight Binding of a Dimeric Derivative of Vancomycin with Dimeric L-Lys-D-Ala-D-Ala”, J. Am. Chem. Soc., vol. 119, pp. 10286-10290 (1997).
Sundram et al., “Novel Vancomycin Dimers with Activity against Vancomycin-Resistant Enterococci”, J. Am. Chem. Soc., vol. 118, pp. 13107-13108 (1996).
Tucker et al., “Piperazinyl Oxazolidinone Antibacterial Agents Containing a Pyridine, Diazene, or Triazene Heteroaromatic Ring”, J. Med. Chem., vol. 41, pp. 3727-3735 (1998).
Abstract: (064) Wang et al., “Novel Dimeric Aminoglycoside Antibiotics:Design, Synthesis & RNA Binding” in the Book of Abstracts, 213th ACS National Meeting in San Francisco, CA, Apr. 13-17, 1997.

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