Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Combination of antigens from multiple bacterial species
Patent
1995-06-07
1999-01-19
Leary, Louise N.
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Combination of antigens from multiple bacterial species
4242381, 4242341, A61K 39116, A61K 3905, A61K 3902
Patent
active
058611622
ABSTRACT:
Novel inocula for administration to ruminant animals such as cattle or sheep are provided in order to immunize the animals and lessen the incidence of liver abscesses and/or foot rot therein. In one aspect, the invention pertains to an A. pyogenes-derived vaccine including an inactivated cell culture product (e.g., cell-elaborated supernatant) from A. pyogenes cell culture in a suitable carrier. In another aspect, the invention relates to a multivalent vaccine including at least first and second bacterial components in a carrier; the first component comprises an inactivated cell culture product of A. pyogenes whereas the second component comprises an inactivated cell culture product of F. necrophorum. The inocula of the present invention find particular utility in incidences where ruminant animals are particularly subject to A. pyogenes infection leading to liver abscesses and/or foot rot, e.g., where the animals are regularly treated with an antibiotic or where cattle are fed a high grain content concentrate diet.
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Chengappa Muckatira M.
Nagaraja Tiruvoor G.
Kansas State University Research Foundation
Leary Louise N.
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