Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Patent
1997-04-11
1999-10-12
Huff, Sheela
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
514 13, 514 14, 514 15, 514 16, 514 17, 514 18, 530323, 530324, 530325, 530326, 530327, 530328, 530329, 530330, C07K 500
Patent
active
059655321
ABSTRACT:
Synthetic crosslinking homobivalent and heterobivalent compounds have been designed and developed. These compounds are low in molecular weight, have antagonistic or agonistic activity, and induce the association between two identical or similar natural receptors (homobivalent compounds) or induce the association between two different natural receptors (heterobivalent compounds).
REFERENCES:
patent: 4318904 (1982-03-01), Shaw et al.
patent: 4443609 (1984-04-01), Alink et al.
patent: 4499082 (1985-02-01), Shenvi et al.
patent: 4582821 (1986-04-01), Kettner et al.
patent: 4636492 (1987-01-01), Kettner et al.
patent: 4644055 (1987-02-01), Kettner et al.
patent: 4652552 (1987-03-01), Kettner et al.
patent: 4935493 (1990-06-01), Bachovchin et al.
patent: 4963655 (1990-10-01), Kinder et al.
patent: 5093477 (1992-03-01), Molling et al.
patent: 5187157 (1993-02-01), Kettner et al.
patent: 5215926 (1993-06-01), Etchells, III et al.
patent: 5242904 (1993-09-01), Kettner et al.
patent: 5250720 (1993-10-01), Kettner et al.
patent: 5288707 (1994-02-01), Metternich
patent: 5296604 (1994-03-01), Hanko et al.
patent: 5329028 (1994-07-01), Ashkenzi et al.
patent: 5378624 (1995-01-01), Berenson et al.
patent: 5384410 (1995-01-01), Kettner et al.
patent: 5444049 (1995-08-01), de Nanteuil et al.
patent: 5462928 (1995-10-01), Bachovchin et al.
patent: 5506130 (1996-04-01), Peterson et al.
patent: 5527923 (1996-06-01), Klingler et al.
patent: 5543396 (1996-08-01), Powers et al.
patent: 5554728 (1996-09-01), Basava et al.
patent: 5635386 (1997-06-01), Palsson et al.
patent: 5635387 (1997-06-01), Fei et al.
patent: 5646043 (1997-07-01), Emerson et al.
Kinder et al J. Med. Chem vol. 33 p. 819, 1990.
Snow et al JACS vol. 116 p. 10860, 1994.
Wiidenes et al., "Monoclonal Antibodies (mAb) against gp130 Imitating Cytokines Which Use the gp130 for Signal Transduction", (Jul., 1995), p. 303.
Blumenstein et al., Biochem. Biophys. Res. Comm. 163:980-987.
ASM News 56:368, 1990.
"Inhibition of Human Immunodeficiency Virus Type 1 Infection in a T-Cell Line (CEM) by New Dipeptidyl-Peptidase IV (CD26) Inhibitors," J.D. Jiang et al., Res. Virol., 1997, 148 pp. 255-266.
"Structure-Activity Relationships of Boronic Acid Inhibitors of Dipeptidyl Peptidase IV. 1. Variation of the P.sub.2 Position of X.sub.oo -boroPro Dipeptides," Simon J. Coutts et al., J. Med. Chem. 1996, 39, pp. 2087-2094.
"Generation and Use of Nonsupport-Bound Peptide and Peptidomimetic Combinatorial Libraries," J.M. Ostresh et al., Methods in Enzymology, vol. 267, Chapter 13, edited by John N. Abelson, 1996, Academic Press, San Diego, ISBN 0-12-182168-4.
Colowick, S., et al., "Methods in Enzymology", pp. 220-225.
Cordes, E., et al., "Transition States for Hydrolysis of Acetals, Ketals Glycosides, and Glycosylamines", Chapter 11, pp. 429-465.
Thompson, R., "Use of Peptide Aldehydes to Generate Transition-State Analogs of Elastase", Biochemistry, (1973), 12:1:47-51.
Bodanszky, M., "Principles of Peptide Synthesis", Springer-Verlag, (1984), vol. 16.
Bodanszky, M., "The Practice of Peptide Synthesis", Springer-Verlag, (1984), vol. 21.
Matteson, D., et al., "Synthesis and Properties of Pinanediol .alpha.-Amido Boronic Esters" Organometallics, (1984), 3:1284-1288.
Powers, C., et al., "Elastase Inhibitors for Treatment of Emphysema--NHLBI Workshop Summary" US Dept. of Health and Human Services, (1985), 1097-1100.
Yoshimoto, T., et al., "Comparison of Inhibitory Effects of Prolinal-Containing Peptide Derivates on Prolyl . . . ", (1985), 98:975-979.
Kettner, C.A., et al., "Kinetic Properties of the Binding of Alpha-Lytic Protease to Peptide Boronic Acids", Biochemistry, (1988), 27:7682-7688.
Tam, J.P., "Synthetic Peptide Vaccine Design: Synthesis and Properties of a High-Density Multiple Antigenic Peptide System", Proc Natl Acad Sci U S A, (1988), 85:5409-5413.
Bailey, P.D., "An Introduction to Pepetide Chemistry", Wiley Publishers, (1990), 1-81--Table of Contents only.
Kettner, C.A. and Shenvi, A.B., "Peptide Boronic Acid Inhibitors of Trypsin-Like Proteases, Their Preparation and Use as Anticoagulants and Inflammation Inhibitors", Chemical Abstracts, (1990), 112:80 (91790c).
Bachovchin, W.W., et al., "Inhibition of IGA1 Proteinases from Neisseria Gonorrhoeae and Hemophilus Influenzae by Peptide Prolyl Boronic Acids", J Biol Chem, (1990), 265: 3738-3743.
Kinder D.H., et al., "Analogues of Carbamyl Aspartate as Inhibitors of Dihydroorotase: Preparation of Boronic Acid Transition-State Analogues and a Zinc Chelator Carbamylhomocysteine", J Med Chem, (1990), 33:819-823.
Flentke, G.R., et al., "Inhibition of Dipeptidyl Aminopeptidase IV (DP-IV) by XAA-Boropro Dipeptides and Use of These Inhibitors to Examine the Role of DP-IV in T-Cell Function", Proc Natl Acad Sci U S A, (1991), 88:1556-1559.
Schon, E., et al., "Dipeptidyl Peptidase IV in the Immune System", Biol Chem Hoppe-Seyler, (1991), 372:305-311.
Kubota, T., et al., "Involvement of Dipeptidyl Peptidase IV in an In Vivo Immune Response", Clin Exp Immunol, (1992), 89:192-197.
Gutheil, W.G., et al., "Separation of L-Pro-DL-Boropro into Its Component Diastereomers and Kinetic Analysis of Their Inhibition of Dipeptidyl Peptidase IV. A New Method for the Analysis of Slow, Tight-Binding Inhibition", Biochemistry, (1993), 32:8723-8731.
Kelly, T.A., et al., "Immunosuppressive Boronic Acid Dipeptides: Correlation Between Conformation and Activity", J Am Chem Soc, (1993), 115:12637-12638.
Songyang, Z., et al., "SH2 Domains Recognize Specific Phosphopeptide Sequences", Cell, (1993), 72:767-778.
Subramanyam, M., et al., "Mechanism of HIV-1 Tat Induced Inhibition of Antigen-Specific T Cell Responsiveness", J Immunol, (1993), 150:2544-2553.
Demuth, H.U., et al., "Design of (Omega-N-(O-Acyl)Hydroxy Amid) Aminodicarboxylic Acid Pyrrolidides as Potent Inhibitors of Proline-Specific Peptidases", FEBS Lett, (1993), 320:23-27.
Janeway, C., et al., "Immunobiology--The Immune System in Health and Disease", Current Biology LTD, (1994), Chapter 12, pp. 1-35.
Brady, L., and Dodson, G., "Reflections on a Peptide", Nature, (1994), 368:692-693.
Nicola, N, et al., "Guidebook to Cytokines and Their Receptors", Sambrook and Tooze Publication, (1994), pp. 1-257.
Perstorp Biotec Company, "Molecular Biology Catalog", (1994)--Table of Contents only.
Jameson, B.A., et al., "A Rationally Designed CD4 Analogue Inhibits Experimental Allergic Encephalomyelitis", Nature, (1994), 368:744-746. Abstract.
Mosmann, T.R., "Cytokine Patterns During the Progression to Aids", Science, (1994), 265:193-194.
Seed, B., "Making Agonists of Antagonists", Chemistry & Biology, (1994), 1:125-129.
Austin, D.J., et al., "Proximity Versus Allostery; The Role of Regulated Protein Dimerization in Biology", Chemistry & Biology, (1994), 1:131-136.
Sudmeier, J.L., et al., "Solution Structures of Active and Inactive Forms of the DP IV (CD26) Inhibitor Pro-Boropro Determined by NMR Spectroscopy", Biochemistry, (1994), 33:12427-12438.
Kubota, T., et al., "Dipeptidyl Peptidase IV (DP IV) Activity in Serum and on Lymphocytes of MRL/Mp-lpr/lpr Mice Correlates with Disease Onset", Clin Exp Immunol, (1994), 96:292-296.
Snow, R.J., et al., "Studies on Proline Boronic Acid Dipeptide Inhibitors of Dipeptidyl Peptidase IV: Identification of a Cyclic Species Containing a B--N Bond", J. Am. Chem. Soc, (1994), 116:10860-10869.
Gunther, U.L., et al., "Solution Structures of the DP IV (CD26) Inhibitor Val-BoroPro Determined by NMR Spectroscopy", Magnetic Resonance in Chem, (1995), 33:959-970.
Subramanyam, M., et al., "CD26, at-Cell Accessory Molecule Induction of Antigen-Specific Immune-Suppression by Inactivation of CD26: A Clue to the Aids Paradox?", in Dipeptidyl Peptidase IV(CD26) in Metabolism and Immune Response, (1995), Ed. B. Fleischer: 155-162.
Bodansky, M., "Peptide Chemistry, a Practical Textbook", Springer-Verlag, (1988) 1-9.
Boros, L.G., et al., "Fluoroolefin Peptide Isosteres-Tools for Controlling Peptide Conformations", Tetrahedron Letters, (1994), 35:6033-6036.
Goodman, M., and Chorev, M., "On the Concept of Linear Modified Retro-Peptide Structures", Accounts of Chemical
Huff Sheela
Trustees of Tufts College
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